Hippocampal involvement in contextual modulation of fear extinction

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dc.contributor.author Ji, Jinzhao
dc.contributor.author Maren, Stephen
dc.date.accessioned 2007-10-02T14:44:44Z
dc.date.available 2007-10-02T14:44:44Z
dc.date.issued 2007-06-29
dc.identifier.citation Hippocampus, 17(9):749-58. <http://hdl.handle.net/2027.42/56197> en_US
dc.identifier.uri http://hdl.handle.net/2027.42/56197
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17604353&dopt=citation en_US
dc.description.abstract Extinction of fear conditioning in animals is an excellent model for the study of fear inhibition in humans. Substantial evidence has shown that extinction is a new learning process that is highly context-dependent. Several recovery effects (renewal, spontaneous recovery, and reinstatement) after extinction suggest that the contextual modulation of extinction is a critical behavioral mechanism underlying fear extinction. In addition, recent studies demonstrate a critical role for hippocampus in the context control of extinction. A growing body of evidence suggests that the hippocampus not only plays a role in contextual encoding and retrieval of fear extinction memories, but also interacts with other brain structures to regulate context-specificity of fear extinction. In this article, the authors will first discuss the fundamental behavioral features of the context effects of extinction and its underlying behavioral mechanisms. In the second part, the review will focus on the brain mechanisms for the contextual control of extinction. (c) 2007 Wiley-Liss, Inc. en_US
dc.format.extent 156529 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US en_US
dc.title Hippocampal involvement in contextual modulation of fear extinction en_US
dc.type Article en_US
dc.subject.hlbsecondlevel Psychology
dc.subject.hlbtoplevel Social Sciences
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationum Department of Psychology en_US
dc.contributor.affiliationumcampus Ann Arbor en_US
dc.identifier.pmid 17604353 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/56197/1/jiHIPP07.pdf en_US
dc.owningcollname Psychology, Department of
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