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dc.contributor.authorMaren, Stephen
dc.contributor.authorBaudry, Michel
dc.contributor.authorThompson, Richard F.
dc.date.accessioned2007-10-02T15:10:58Z
dc.date.available2007-10-02T15:10:58Z
dc.date.issued1991-05
dc.identifier.citationNeuroreport, 2(5):239-42. <http://hdl.handle.net/2027.42/56198>en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/56198
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1832985&dopt=citationen_US
dc.description.abstractKetamine and MK-801 are phencyclidine (PCP)-like noncompetitive antagonists of the N-methyl-D-aspartate (NMDA) receptor that produce a use-dependent blockade of the NMDA receptor-coupled channel. Recent studies have suggested that the binding properties of these drugs to the NMDA receptor in-vitro are different. In the present study, the effects of ketamine and MK-801 on the induction of long-term potentiation (LTP) were compared at perforant path--granule cell synapses in anaesthetized rats. LTP was observed in animals treated with either saline or MK-801, but not in those treated with ketamine. These results reveal that ketamine and MK-801 differentially modulate the induction of LTP, and we propose that this differential modulation may be related to the different binding properties of the drugs.en_US
dc.format.extent473813 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.titleDifferential effects of ketamine and MK-801 on the induction of long-term potentiationen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPsychology
dc.subject.hlbtoplevelSocial Sciences
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationotherUniversity of Southern Californiaen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid1832985en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/56198/1/marenNREP91.pdfen_US
dc.owningcollnamePsychology, Department of


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