Differential effects of ketamine and MK-801 on the induction of long-term potentiation
dc.contributor.author | Maren, Stephen | |
dc.contributor.author | Baudry, Michel | |
dc.contributor.author | Thompson, Richard F. | |
dc.date.accessioned | 2007-10-02T15:10:58Z | |
dc.date.available | 2007-10-02T15:10:58Z | |
dc.date.issued | 1991-05 | |
dc.identifier.citation | Neuroreport, 2(5):239-42. <http://hdl.handle.net/2027.42/56198> | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/56198 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1832985&dopt=citation | en_US |
dc.description.abstract | Ketamine and MK-801 are phencyclidine (PCP)-like noncompetitive antagonists of the N-methyl-D-aspartate (NMDA) receptor that produce a use-dependent blockade of the NMDA receptor-coupled channel. Recent studies have suggested that the binding properties of these drugs to the NMDA receptor in-vitro are different. In the present study, the effects of ketamine and MK-801 on the induction of long-term potentiation (LTP) were compared at perforant path--granule cell synapses in anaesthetized rats. LTP was observed in animals treated with either saline or MK-801, but not in those treated with ketamine. These results reveal that ketamine and MK-801 differentially modulate the induction of LTP, and we propose that this differential modulation may be related to the different binding properties of the drugs. | en_US |
dc.format.extent | 473813 bytes | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en_US | en_US |
dc.title | Differential effects of ketamine and MK-801 on the induction of long-term potentiation | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Psychology | |
dc.subject.hlbtoplevel | Social Sciences | |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationother | University of Southern California | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 1832985 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/56198/1/marenNREP91.pdf | en_US |
dc.owningcollname | Psychology, Department of |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.