A negative correlation between the induction of long-term potentiation and activation of immediate early genes

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dc.contributor.author Schreiber, Steven S.
dc.contributor.author Maren, Stephen
dc.contributor.author Tocco, Georges
dc.contributor.author Shors, Tracey J.
dc.contributor.author Thompson, Richard F.
dc.date.accessioned 2007-10-02T15:19:29Z
dc.date.available 2007-10-02T15:19:29Z
dc.date.issued 1991-08
dc.identifier.citation Molecular Brain Research, 11(1):89-91. <http://hdl.handle.net/2027.42/56200> en_US
dc.identifier.uri http://hdl.handle.net/2027.42/56200
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1662748&dopt=citation en_US
dc.description.abstract In the present study we examined the relationship between the induction of long-term potentiation (LTP) in the dentate gyrus of anesthetized rats and activation of immediate early genes (IEGs; c-fos and zif/268) using several different high-frequency stimulation paradigms. Stimulation parameters that effectively induced LTP were not associated with IEG activation. Conversely, stimulation parameters that failed to induce LTP consistently resulted in IEG activation. These results suggest that there is a negative correlation between IEG activation and LTP, and that activation of IEGs is neither necessary nor sufficient for the induction of LTP. en_US
dc.format.extent 477177 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US en_US
dc.title A negative correlation between the induction of long-term potentiation and activation of immediate early genes en_US
dc.type Article en_US
dc.subject.hlbsecondlevel Psychology
dc.subject.hlbtoplevel Social Sciences
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationother University of Southern California en_US
dc.contributor.affiliationumcampus Ann Arbor en_US
dc.identifier.pmid 1662748 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/56200/1/schreiberMBRES91.pdf en_US
dc.owningcollname Psychology, Department of
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