Effects of the novel NMDA receptor antagonist, CGP 39551, on field potentials and the induction and expression of LTP in the dentate gyrus in vivo

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dc.contributor.author Maren, Stephen
dc.contributor.author Baudry, Michel
dc.contributor.author Thompson, Richard F.
dc.date.accessioned 2007-10-02T15:31:20Z
dc.date.available 2007-10-02T15:31:20Z
dc.date.issued 1992-07
dc.identifier.citation Synapse, 11(3):221-8. <http://hdl.handle.net/2027.42/56202> en_US
dc.identifier.uri http://hdl.handle.net/2027.42/56202
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=1353274&dopt=citation en_US
dc.description.abstract The effects of the novel competitive N-methyl-D-aspartate (NMDA) receptor antagonist, CGP 39551 [the carboxyethylester of CGP 37849; DL-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid], on extracellular field potentials and long-term potentiation (LTP) induced in the dentate gyrus by stimulation of the perforant path were studied in anesthetized rats. CGP 39551 attenuated the population spike (PS) and excitatory postsynaptic potential (EPSP) amplitude of dentate field potentials, reduced the NMDA receptor-mediated component of train-evoked burst potentials, and prevented the induction of LTP. The decrease in PS and EPSP amplitude produced by CGP 39551 was observed mainly in non-potentiated synaptic populations; potentiated field potentials were only minimally affected by drug treatment. These results are consistent with receptors may contribute in a tonic manner to the state of dentate granule cell excitability. Finally, the differential modulation of potentiated and non-potentiated synapses by CGP 39551 suggests that a change in some properties of postsynaptic AMPA receptors is involved in the expression of LTP. en_US
dc.format.extent 1310522 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US en_US
dc.title Effects of the novel NMDA receptor antagonist, CGP 39551, on field potentials and the induction and expression of LTP in the dentate gyrus in vivo en_US
dc.type Article en_US
dc.subject.hlbsecondlevel Psychology
dc.subject.hlbtoplevel Social Sciences
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationother University of Southern California en_US
dc.contributor.affiliationumcampus Ann Arbor en_US
dc.identifier.pmid 1353274 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/56202/1/marenSYN92.pdf en_US
dc.owningcollname Psychology, Department of
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