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Parallel augmentation of hippocampal long-term potentiation, theta rhythm, and contextual fear conditioning in water-deprived rats

dc.contributor.authorMaren, Stephen
dc.contributor.authorDeCola, Joseph P.
dc.contributor.authorSwain, Rodney A.
dc.contributor.authorFanselow, Michael S.
dc.contributor.authorThompson, Richard F.
dc.identifier.citationBehavioral Neuroscience, 108(1):44-56. <>en_US
dc.description.abstractThe influence of water deprivation on hippocampal long-term potentiation (LTP), theta rhythm, and contextual fear conditioning in rats was examined. In Experiment 1, hippocampal EEG activity and perforant path LTP were assessed in pentobarbital-anesthetized rats. Water deprivation did not affect baseline cell excitability or low-frequency synaptic transmission in the dentate gyrus, but it increased the magnitude of perforant path LTP and elevated the proportion of theta rhythm in the EEG. In Experiment 2, rats were classically conditioned to fear a novel context through the use of aversive footshocks. Water deprivation facilitated the rate of contextual fear conditioning but did not alter the asymptote of learning. Experiment 3 demonstrated that the facilitation of contextual fear conditioning was not due to a change in unconditional shock sensitivity. These results suggest that water deprivation exerts an influence on contextual fear conditioning by modulating hippocampal LTP and theta rhythm and that these processes serve to encode contextual information during learning.en_US
dc.format.extent2192933 bytes
dc.titleParallel augmentation of hippocampal long-term potentiation, theta rhythm, and contextual fear conditioning in water-deprived ratsen_US
dc.subject.hlbtoplevelSocial Sciences
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationotherUniversity of Southern Californiaen_US
dc.contributor.affiliationotherUniversity of California, Los Angelesen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.owningcollnamePsychology, Department of

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