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dc.contributor.authorMaren, Stephen
dc.contributor.authorTocco, Georges
dc.contributor.authorChavanne, Frederic
dc.contributor.authorBaudry, Michel
dc.contributor.authorThompson, Richard F.
dc.contributor.authorMitchell, Denis
dc.date.accessioned2007-10-02T17:24:26Z
dc.date.available2007-10-02T17:24:26Z
dc.date.issued1994-07
dc.identifier.citationBehavioral and Neural Biology, 62(1):68-72. <http://hdl.handle.net/2027.42/56208>en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/56208
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7945147&dopt=citationen_US
dc.description.abstractPrevious work from our laboratory indicated that emergence neophobia is highly correlated with perforant path long-term potentiation (LTP) in rats. In the present study, we examined the relationship between hippocampal and cortical alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptors and emergence behavior in rats. Emergence neophobia was assessed in an exploratory task that provided a choice between a novel alley and a familiar nest box. Quantitative autoradiography using radiolabeled ligands specific for the AMPA subclass of glutamate receptors was performed on frozen brain sections. Both [3H]AMPA and [3H]CNQX (6-cyano-7-nitro-[3H]quinoxaline- 2,3-dione, an AMPA receptor antagonist) binding in the dentate gyrus (stratum moleculare), hippocampal area CA1 (stratum radiatum), and the parietal cortex overlying the hippocampus were significantly correlated with emergence behavior. The correlations indicated that neophobic rats, which had longer latencies to enter the novel alley, made fewer entries into the alley, and spent less time in the novel alley during a 10-min test than their neophilic counterparts, had higher levels of AMPA receptor binding. These results suggest that individual differences in specific hippocampal AMPA receptors reflect variability in a specific class of hippocampal-dependent behaviors.en_US
dc.format.extent766554 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.titleEmergence neophobia correlates with hippocampal and cortical glutamate receptor binding in ratsen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPsychology
dc.subject.hlbtoplevelSocial Sciences
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationotherUniversity of Southern Californiaen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid7945147en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/56208/1/marenBNB94.pdfen_US
dc.owningcollnamePsychology, Department of


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