Sex differences in hippocampal long-term potentiation (LTP) and Pavlovian fear conditioning in rats: positive correlation between LTP and contextual learning

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dc.contributor.author Maren, Stephen
dc.contributor.author De Oca, Beatrice
dc.contributor.author Fanselow, Michael S.
dc.date.accessioned 2007-10-02T17:27:16Z
dc.date.available 2007-10-02T17:27:16Z
dc.date.issued 1994-10
dc.identifier.citation Brain Research, 661(1-2):25-34. <http://hdl.handle.net/2027.42/56209> en_US
dc.identifier.uri http://hdl.handle.net/2027.42/56209
dc.identifier.uri http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=7834376&dopt=citation en_US
dc.description.abstract Three experiments investigated sex differences in hippocampal long-term potentiation (LTP) and Pavlovian fear conditioning in rats. Experiment 1 revealed a robust sex difference in the magnitude of LTP induced at perforant path synapses in the dentate gyrus of pentobarbital-anesthetized rats. This sex difference in LTP was evident in rats of 35 and 60 days of age and was not the result of pre-LTP sex differences in perforant path synaptic transmission; 20-day-old rats did not show LTP. An analysis of field potentials evoked during LTP induction revealed a sex difference in the magnitude of N-methyl-D-aspartate (NMDA) receptor activation that was highly correlated with the magnitude of LTP. Experiment 2 showed that males condition more fear, measured as freezing, to the contextual conditional stimuli (CSs) of a conditioning chamber compared to their female counterparts. This sex difference in conditional freezing was apparent with both low and high unconditional stimulus (US, footshock) intensities. Experiment 3 revealed that the enhanced fear conditioning in males was specific to contextual CSs, and consisted of a more rapid rate of conditioning. Together, these experiments reveal a positive correlation between the magnitude of hippocampal LTP and a form of learning that depends on the hippocampus. Furthermore, they suggest a neural basis for sex differences in hippocampus-dependent learning tasks. en_US
dc.format.extent 1514690 bytes
dc.format.mimetype application/pdf
dc.language.iso en_US en_US
dc.title Sex differences in hippocampal long-term potentiation (LTP) and Pavlovian fear conditioning in rats: positive correlation between LTP and contextual learning en_US
dc.type Article en_US
dc.subject.hlbsecondlevel Psychology
dc.subject.hlbtoplevel Social Sciences
dc.description.peerreviewed Peer Reviewed en_US
dc.contributor.affiliationother University of California, Los Angeles en_US
dc.contributor.affiliationumcampus Ann Arbor en_US
dc.identifier.pmid 7834376 en_US
dc.description.bitstreamurl http://deepblue.lib.umich.edu/bitstream/2027.42/56209/1/marenBRES94.pdf en_US
dc.owningcollname Psychology, Department of
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