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dc.contributor.authorAnagnostaras, Stephan G.
dc.contributor.authorMaren, Stephen
dc.contributor.authorFanselow, Michael S.
dc.date.accessioned2007-10-02T17:41:43Z
dc.date.available2007-10-02T17:41:43Z
dc.date.issued1995-11
dc.identifier.citationNeurobiology of Learning and Memory, 64(3):191-4. <http://hdl.handle.net/2027.42/56213>en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/56213
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8564372&dopt=citationen_US
dc.description.abstractMuscarinic cholinergic antagonism produces learning and memory deficits in a variety of hippocampal-dependent tasks. Hippocampal lesions produce both acquisition deficits and retrograde amnesia for contextual fear conditioning, but do not impact fear conditioning to discrete cues. In order to examine the effects of muscarinic antagonism in this paradigm, rats were given scopolamine (1 mg/kg) either before or for 3 days after a Pavlovian fear-conditioning session in which tones were paired with aversive footshocks. Fear to the context and the tone was assessed by measuring freezing in separate tests. It ws found that pretraining, but not posttraining, scopolamine severely impaired contextual fear conditioning; tone conditioning was not affected under either condition (cf., Young, Bohenek, & Fanselow, Neurobiology of Learning and Memory, 63, 174-180, 1995).en_US
dc.format.extent54232 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.titleScopolamine selectively disrupts the acquisition of contextual fear conditioning in ratsen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPsychology
dc.subject.hlbtoplevelSocial Sciences
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationotherUniversity of California, Los Angelesen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid8564372en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/56213/1/anagNLM95.pdfen_US
dc.owningcollnamePsychology, Department of


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