Scopolamine selectively disrupts the acquisition of contextual fear conditioning in rats
dc.contributor.author | Anagnostaras, Stephan G. | |
dc.contributor.author | Maren, Stephen | |
dc.contributor.author | Fanselow, Michael S. | |
dc.date.accessioned | 2007-10-02T17:41:43Z | |
dc.date.available | 2007-10-02T17:41:43Z | |
dc.date.issued | 1995-11 | |
dc.identifier.citation | Neurobiology of Learning and Memory, 64(3):191-4. <http://hdl.handle.net/2027.42/56213> | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/56213 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8564372&dopt=citation | en_US |
dc.description.abstract | Muscarinic cholinergic antagonism produces learning and memory deficits in a variety of hippocampal-dependent tasks. Hippocampal lesions produce both acquisition deficits and retrograde amnesia for contextual fear conditioning, but do not impact fear conditioning to discrete cues. In order to examine the effects of muscarinic antagonism in this paradigm, rats were given scopolamine (1 mg/kg) either before or for 3 days after a Pavlovian fear-conditioning session in which tones were paired with aversive footshocks. Fear to the context and the tone was assessed by measuring freezing in separate tests. It ws found that pretraining, but not posttraining, scopolamine severely impaired contextual fear conditioning; tone conditioning was not affected under either condition (cf., Young, Bohenek, & Fanselow, Neurobiology of Learning and Memory, 63, 174-180, 1995). | en_US |
dc.format.extent | 54232 bytes | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en_US | en_US |
dc.title | Scopolamine selectively disrupts the acquisition of contextual fear conditioning in rats | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Psychology | |
dc.subject.hlbtoplevel | Social Sciences | |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationother | University of California, Los Angeles | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.identifier.pmid | 8564372 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/56213/1/anagNLM95.pdf | en_US |
dc.owningcollname | Psychology, Department of |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.