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Synaptic transmission and plasticity in the amygdala: an emerging physiology of fear conditioning circuits

dc.contributor.authorMaren, Stephen
dc.date.accessioned2007-10-02T19:35:59Z
dc.date.available2007-10-02T19:35:59Z
dc.date.issued1996-08
dc.identifier.citationMolecular Neurobiology, 13(1):1-22. <http://hdl.handle.net/2027.42/56216>en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/56216
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=8892333&dopt=citationen_US
dc.description.abstractNumerous studies in both rats and humans indicate the importance of the amygdala in the acquisition and expression of learned fear. The identification of the amygdala as an essential neural substrate for fear conditioning has permitted neurophysiological examinations of synaptic processes in the amygdala that may mediate fear conditioning. One candidate cellular mechanism for fear conditioning is long-term potentiation (LTP), an enduring increase in synaptic transmission induced by high-frequency stimulation of excitatory afferents. At present, the mechanisms underlying the induction and expression of amygdaloid LTP are only beginning to be understood, and probably involve both the N-methyl-D-aspartate (NMDA) and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) subclasses of glutamate receptors. This article will examine recent studies of synaptic transmission and plasticity in the amygdala in an effort to understand the relationships of these processes to aversive learning and memory.en_US
dc.format.extent3213590 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.titleSynaptic transmission and plasticity in the amygdala: an emerging physiology of fear conditioning circuitsen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPsychology
dc.subject.hlbtoplevelSocial Sciences
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Psychologyen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid8892333en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/56216/1/marenMN96.pdfen_US
dc.owningcollnamePsychology, Department of


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