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Selective enhancement of emotional, but not motor, learning in monoamine oxidase A-deficient mice

dc.contributor.authorKim, Jeansok J.
dc.contributor.authorShih, Jean C.
dc.contributor.authorChen, Kevin
dc.contributor.authorChen, Lu
dc.contributor.authorBao, Shaowen
dc.contributor.authorMaren, Stephen
dc.contributor.authorAnagnostaras, Stephan G.
dc.contributor.authorFanselow, Michael S.
dc.contributor.authorDe Maeyer, Edward D.
dc.contributor.authorSeif, Isabelle
dc.contributor.authorThompson, Richard F.
dc.date.accessioned2007-10-08T15:06:02Z
dc.date.available2007-10-08T15:06:02Z
dc.date.issued1997-05-27
dc.identifier.citationProceedings of the National Academy of Science (USA), 94(11):5929-33. <http://hdl.handle.net/2027.42/56225>en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/56225
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9159177&dopt=citationen_US
dc.description.abstractMice deficient in monoamine oxidase A (MAOA), an enzyme that metabolizes monoamines such as norepinephrine and serotonin, have elevated norepinephrine and serotonin levels in the frontal cortex, hippocampus, and cerebellum, compared with normal wild-type mice. Since monoamines in these areas are critically involved in a variety of behaviors, we examined learning and memory (using emotional and motor tasks) in MAOA mutant mice. The MAOA-deficient mice exhibited significantly enhanced classical fear conditioning (freezing to both tone and contextual stimuli) and step-down inhibitory avoidance learning. In contrast, eyeblink conditioning was normal in these mutant mice. The female MAOA-deficient mice also displayed normal species-typical maternal behaviors (nesting, nursing, and pup retrieval). These results suggest that chronic elevations of monoamines, due to a deletion of the gene encoding MAOA, lead to selective alterations in emotional behavior.en_US
dc.format.extent258696 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.titleSelective enhancement of emotional, but not motor, learning in monoamine oxidase A-deficient miceen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPsychology
dc.subject.hlbtoplevelSocial Sciences
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationotherUniversity of Southern Californiaen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid9159177en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/56225/1/kimPNAS97.pdfen_US
dc.owningcollnamePsychology, Department of


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