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dc.contributor.authorKim, Jeansok J.
dc.contributor.authorShih, Jean C.
dc.contributor.authorChen, Kevin
dc.contributor.authorChen, Lu
dc.contributor.authorBao, Shaowen
dc.contributor.authorMaren, Stephen
dc.contributor.authorAnagnostaras, Stephan G.
dc.contributor.authorFanselow, Michael S.
dc.contributor.authorDe Maeyer, Edward D.
dc.contributor.authorSeif, Isabelle
dc.contributor.authorThompson, Richard F.
dc.date.accessioned2007-10-08T15:06:02Z
dc.date.available2007-10-08T15:06:02Z
dc.date.issued1997-05-27
dc.identifier.citationProceedings of the National Academy of Science (USA), 94(11):5929-33. <http://hdl.handle.net/2027.42/56225>en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/56225
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=9159177&dopt=citationen_US
dc.description.abstractMice deficient in monoamine oxidase A (MAOA), an enzyme that metabolizes monoamines such as norepinephrine and serotonin, have elevated norepinephrine and serotonin levels in the frontal cortex, hippocampus, and cerebellum, compared with normal wild-type mice. Since monoamines in these areas are critically involved in a variety of behaviors, we examined learning and memory (using emotional and motor tasks) in MAOA mutant mice. The MAOA-deficient mice exhibited significantly enhanced classical fear conditioning (freezing to both tone and contextual stimuli) and step-down inhibitory avoidance learning. In contrast, eyeblink conditioning was normal in these mutant mice. The female MAOA-deficient mice also displayed normal species-typical maternal behaviors (nesting, nursing, and pup retrieval). These results suggest that chronic elevations of monoamines, due to a deletion of the gene encoding MAOA, lead to selective alterations in emotional behavior.en_US
dc.format.extent258696 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.titleSelective enhancement of emotional, but not motor, learning in monoamine oxidase A-deficient miceen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPsychology
dc.subject.hlbtoplevelSocial Sciences
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationotherUniversity of Southern Californiaen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.identifier.pmid9159177en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/56225/1/kimPNAS97.pdfen_US
dc.owningcollnamePsychology, Department of


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