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dc.contributor.authorHolt, William
dc.contributor.authorMaren, Stephen
dc.date.accessioned2007-10-08T16:01:58Z
dc.date.available2007-10-08T16:01:58Z
dc.date.issued1999-10-15
dc.identifier.citationJournal of Neuroscience, 19(20):9054-62. <http://hdl.handle.net/2027.42/56237>en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/56237
dc.description.abstractSome models of hippocampal function have suggested a role of the hippocampus in contextual memory retrieval. We have examined this hypothesis by assessing the impact of reversible inactivation of the dorsal hippocampus (DH) on the context-specific expression of latent inhibition, a decrement in conditional responding produced by preexposure to a to-be-conditional stimulus. In Experiment 1, rats received tone preexposure either in the context that would later be used for extinction testing (context A) or in a different context (context C); a third group of rats did not receive tone preexposure. All rats then received fear conditioning, which consisted of tone-footshock pairings, in a third distinct context (context B). The following day conditional fear to the tone was assessed in one of the preexposure contexts (context A) by measuring freezing during a tone extinction test. Rats preexposed and tested in the same context exhibited less freezing to the tone than either rats preexposed and tested in different contexts or non-preexposed rats. These results indicate that the expression of latent inhibition is context specific. In Experiment 2, DH inactivation eliminated the context-specific expression of latent inhibition. Compared with saline-infused rats, rats infused with muscimol into the DH exhibited low levels of tone freezing independent of whether they had received tone preexposure in the test context or in a different context. Experiment 3 revealed normal contextual discrimination in rats after DH inactivation. These results suggest the DH is required for contextual memory retrieval in a latent inhibition paradigm.en_US
dc.format.extent291314 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_USen_US
dc.titleMuscimol inactivation of the dorsal hippocampus impairs contextual retrieval of fear memoryen_US
dc.typeArticleen_US
dc.subject.hlbsecondlevelPsychology
dc.subject.hlbtoplevelSocial Sciences
dc.contributor.affiliationumDepartment of Psychology and Neuroscience Programen_US
dc.contributor.affiliationumcampusAnn Arboren_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/56237/1/holtJN99.pdfen_US
dc.owningcollnamePsychology, Department of


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