Muscimol inactivation of the dorsal hippocampus impairs contextual retrieval of fear memory
dc.contributor.author | Holt, William G. | |
dc.contributor.author | Maren, Stephen | |
dc.date.accessioned | 2007-10-08T16:01:58Z | |
dc.date.available | 2007-10-08T16:01:58Z | |
dc.date.issued | 1999-10-15 | |
dc.identifier.citation | Journal of Neuroscience, 19(20):9054-62. <http://hdl.handle.net/2027.42/56237> | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/56237 | |
dc.description.abstract | Some models of hippocampal function have suggested a role of the hippocampus in contextual memory retrieval. We have examined this hypothesis by assessing the impact of reversible inactivation of the dorsal hippocampus (DH) on the context-specific expression of latent inhibition, a decrement in conditional responding produced by preexposure to a to-be-conditional stimulus. In Experiment 1, rats received tone preexposure either in the context that would later be used for extinction testing (context A) or in a different context (context C); a third group of rats did not receive tone preexposure. All rats then received fear conditioning, which consisted of tone-footshock pairings, in a third distinct context (context B). The following day conditional fear to the tone was assessed in one of the preexposure contexts (context A) by measuring freezing during a tone extinction test. Rats preexposed and tested in the same context exhibited less freezing to the tone than either rats preexposed and tested in different contexts or non-preexposed rats. These results indicate that the expression of latent inhibition is context specific. In Experiment 2, DH inactivation eliminated the context-specific expression of latent inhibition. Compared with saline-infused rats, rats infused with muscimol into the DH exhibited low levels of tone freezing independent of whether they had received tone preexposure in the test context or in a different context. Experiment 3 revealed normal contextual discrimination in rats after DH inactivation. These results suggest the DH is required for contextual memory retrieval in a latent inhibition paradigm. | en_US |
dc.format.extent | 291314 bytes | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en_US | en_US |
dc.title | Muscimol inactivation of the dorsal hippocampus impairs contextual retrieval of fear memory | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Psychology | |
dc.subject.hlbtoplevel | Social Sciences | |
dc.contributor.affiliationum | Department of Psychology and Neuroscience Program | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/56237/1/holtJN99.pdf | en_US |
dc.owningcollname | Psychology, Department of |
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