Focus on function: Single molecule RNA enzymology
dc.contributor.author | Ditzler, Mark A. | en_US |
dc.contributor.author | Alemán, Elvin A. | en_US |
dc.contributor.author | Rueda, David | en_US |
dc.contributor.author | Walter, Nils G. | en_US |
dc.date.accessioned | 2007-12-04T18:24:28Z | |
dc.date.available | 2009-01-07T20:01:16Z | en_US |
dc.date.issued | 2007-12-05 | en_US |
dc.identifier.citation | Ditzler, Mark A.; AlemÁn, Elvin A.; Rueda, David; Walter, Nils G. (2007). "Focus on function: Single molecule RNA enzymology." Biopolymers 87(5-6): 302-316. <http://hdl.handle.net/2027.42/57325> | en_US |
dc.identifier.issn | 0006-3525 | en_US |
dc.identifier.issn | 1097-0282 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/57325 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17685395&dopt=citation | en_US |
dc.description.abstract | The ability of RNA to catalyze chemical reactions was first demonstrated 25 years ago with the discovery that group I introns and RNase P function as RNA enzymes (ribozymes). Several additional ribozymes were subsequently identified, most notably the ribosome, followed by intense mechanistic studies. More recently, the introduction of single molecule tools has dissected the kinetic steps of several ribozymes in unprecedented detail and has revealed surprising heterogeneity not evident from ensemble approaches. Still, many fundamental questions of how RNA enzymes work at the molecular level remain unanswered. This review surveys the current status of our understanding of RNA catalysis at the single molecule level and discusses the existing challenges and opportunities in developing suitable assays. © 2007 Wiley Periodicals, Inc. Biopolymers 87: 302–316, 2007. This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com | en_US |
dc.format.extent | 1049220 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Polymer and Materials Science | en_US |
dc.title | Focus on function: Single molecule RNA enzymology | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Materials Science and Engineering | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Biophysics Research Division, Single Molecule Analysis Group, University of Michigan, Ann Arbor, MI 48109 | en_US |
dc.contributor.affiliationum | Department of Chemistry, Single Molecule Analysis Group, University of Michigan, Ann Arbor, MI 48109 ; Department of Chemistry, Single Molecule Analysis Group, University of Michigan, Ann Arbor, MI 48109 | en_US |
dc.contributor.affiliationother | Department of Chemistry, Wayne State University, Detroit, MI 48202 | en_US |
dc.contributor.affiliationother | Department of Chemistry, Wayne State University, Detroit, MI 48202 ; Department of Chemistry, Wayne State University, Detroit, MI 48202Department of Chemistry, Wayne State University, Detroit, MI 48202 | en_US |
dc.identifier.pmid | 17685395 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/57325/1/20819_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/bip.20819 | en_US |
dc.identifier.source | Biopolymers | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.