Importance of RNA-protein interactions in bacterial ribonuclease P structure and catalysis
dc.contributor.author | Smith, J. Kristin | en_US |
dc.contributor.author | Hsieh, John | en_US |
dc.contributor.author | Fierke, Carol A. | en_US |
dc.date.accessioned | 2007-12-04T18:24:49Z | |
dc.date.available | 2009-01-07T20:01:16Z | en_US |
dc.date.issued | 2007-12-05 | en_US |
dc.identifier.citation | Smith, J. Kristin; Hsieh, John; Fierke, Carol A. (2007). "Importance of RNA-protein interactions in bacterial ribonuclease P structure and catalysis." Biopolymers 87(5-6): 329-338. <http://hdl.handle.net/2027.42/57327> | en_US |
dc.identifier.issn | 0006-3525 | en_US |
dc.identifier.issn | 1097-0282 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/57327 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17868095&dopt=citation | en_US |
dc.description.abstract | Ribonuclease P (RNase P) is a ribonucleoprotein (RNP) complex that catalyzes the metal-dependent maturation of the 5′ end of precursor tRNAs (pre-tRNAs) in all organisms. RNase P is comprised of a catalytic RNA (P RNA), and at least one essential protein (P protein). Although P RNA is the catalytic subunit of the enzyme and is active in the absence of P protein under high salt concentrations in vitro, the protein is still required for enzyme activity in vivo. Therefore, the function of the P protein and how it interacts with both P RNA and pre-tRNA have been the focus of much ongoing research. RNA-protein interactions in RNase P serve a number of critical roles in the RNP including stabilizing the structure, and enhancing the affinity for substrates and metal ions. This review examines the role of RNA-protein interactions in bacterial RNase P from both structural and mechanistic perspectives. © 2007 Wiley Periodicals, Inc. Biopolymers 87: 329–338, 2007. This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com | en_US |
dc.format.extent | 628873 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Polymer and Materials Science | en_US |
dc.title | Importance of RNA-protein interactions in bacterial ribonuclease P structure and catalysis | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Chemical Engineering | en_US |
dc.subject.hlbsecondlevel | Chemistry | en_US |
dc.subject.hlbsecondlevel | Materials Science and Engineering | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Chemistry, University of Michigan, 930 N. University Avenue, Ann Arbor, MI 48109 | en_US |
dc.contributor.affiliationum | Department of Chemistry, University of Michigan, 930 N. University Avenue, Ann Arbor, MI 48109 | en_US |
dc.contributor.affiliationum | Department of Chemistry, University of Michigan, 930 N. University Avenue, Ann Arbor, MI 48109 ; Department of Biological Chemistry, University of Michigan, 930 N. University Avenue, Ann Arbor, MI 48109 ; Department of Chemistry, University of Michigan, 930 N. University Avenue, Ann Arbor, MI 48109 | en_US |
dc.identifier.pmid | 17868095 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/57327/1/20846_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/bip.20846 | en_US |
dc.identifier.source | Biopolymers | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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