TLR9 activation is a key event for the maintenance of a mycobacterial antigen-elicited pulmonary granulomatous response
dc.contributor.author | Ito, Toshihiro | en_US |
dc.contributor.author | Schaller, Matthew A. | en_US |
dc.contributor.author | Hogaboam, Cory M. | en_US |
dc.contributor.author | Standiford, Theodore J. | en_US |
dc.contributor.author | Chensue, Stephen W. | en_US |
dc.date.accessioned | 2007-12-04T18:25:32Z | |
dc.date.available | 2008-11-05T15:05:43Z | en_US |
dc.date.issued | 2007-10 | en_US |
dc.identifier.citation | Ito, Toshihiro; Schaller, Matthew; Hogaboam, Cory M.; Standiford, Theodore J.; Chensue, Stephen W. (2007). "TLR9 activation is a key event for the maintenance of a mycobacterial antigen-elicited pulmonary granulomatous response." European Journal of Immunology 37(10): 2847-2855. <http://hdl.handle.net/2027.42/57331> | en_US |
dc.identifier.issn | 0014-2980 | en_US |
dc.identifier.issn | 1521-4141 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/57331 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17853411&dopt=citation | |
dc.description.abstract | Type 1 (Th1) granulomas can be studied in mice sensitized with mycobacterium antigens followed by challenge of agarose beads covalently coupled to purified protein derivative. TLR9 is known to play a role in the regulation of Th1 responses; thus, we investigated the role of TLR9 in granuloma formation during challenge with mycobacterium antigens and demonstrated that mice deficient in TLR9 had increased granuloma formation, but a dramatically altered cytokine phenotype. Th1 cytokine levels of IFN-γ and IL-12 in the lungs were decreased in TLR9 –/– mice when compared to wild-type mice. In contrast, Th2 cytokine levels of IL-4, IL-5, and IL-13 were increased in TLR9 –/– mice. The migration of CD4 + T cells in the granuloma was impaired, while the number of F4/80 + macrophages was increased in TLR9 –/– mice. Macrophages in the lungs of the TLR9-deficient animals with developing granulomas expressed significantly lower levels of the classically activated macrophage marker, nitric oxide synthase, but higher levels of the alternatively activated macrophage markers such as ‘found in inflammatory zone-1′ antigen and Arginase-1. These results suggest that TLR9 plays an important role in maintaining the appropriate phenotype in a Th1 granulomatous response. | en_US |
dc.format.extent | 368177 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | WILEY-VCH Verlag | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Microbiology and Immunology | en_US |
dc.title | TLR9 activation is a key event for the maintenance of a mycobacterial antigen-elicited pulmonary granulomatous response | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA ; Second Department of Internal Medicine, Nara Medical University, Nara, Japan | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Michigan Medical Center, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan Medical School, Ann Arbor, MI, USA ; Department of Pathology and Laboratory Medicine, Veterans Affairs Ann Arbor Healthcare System, Ann Arbor, MI, USA | en_US |
dc.identifier.pmid | 17853411 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/57331/1/2847_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/eji.200737603 | en_US |
dc.identifier.source | European Journal of Immunology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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