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Sentinel lymph node biopsy for breast cancer: How many nodes are enough?

dc.contributor.authorZakaria, Shaheenen_US
dc.contributor.authorDegnim, Amy C.en_US
dc.contributor.authorKleer, Celina G.en_US
dc.contributor.authorDiehl, Kathleen A.en_US
dc.contributor.authorCimmino, Vincent M.en_US
dc.contributor.authorChang, Alfred E.en_US
dc.contributor.authorNewman, Lisa A.en_US
dc.contributor.authorSabel, Michael S.en_US
dc.date.accessioned2007-12-04T18:26:32Z
dc.date.available2009-01-07T20:01:17Zen_US
dc.date.issued2007-12-01en_US
dc.identifier.citationZakaria, Shaheen; Degnim, Amy C.; Kleer, Celina G.; Diehl, Kathleen A.; Cimmino, Vincent M.; Chang, Alfred E.; Newman, Lisa A.; Sabel, Michael S. (2007). "Sentinel lymph node biopsy for breast cancer: How many nodes are enough?." Journal of Surgical Oncology 96(7): 554-559. <http://hdl.handle.net/2027.42/57337>en_US
dc.identifier.issn0022-4790en_US
dc.identifier.issn1096-9098en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/57337
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17685432&dopt=citationen_US
dc.description.abstractIntroduction Sentinel lymph node (SLN) biopsy using blue dye and radioisotope often results in the removal of multiple SLNs. We sought to determine whether there is a point where the surgeon can terminate the procedure without sacrificing accuracy. Methods One thousand one hundred ninety-seven patients from University of Michigan and the Mayo Clinic undergoing SLN biopsy formed the study population. Surgeons removed all SLNs until counts within the axilla were less than 10% of the highest node ex vivo and recorded the order in which they were removed. Results The mean number of SLNs removed per patient was 2.5 (range 1–9). Approximately 42% of patients had three or more lymph nodes removed, while 19% had four or more lymph nodes removed. Eighteen percent of patients (132/725) at University of Michigan and 22% (103/472) at Mayo Clinic had a positive SLN. Ninety-eight percent (231/235) of patients with lymph node metastases were identified by the 3rd SLN while 100% were identified by the 4th SLN. Conclusion Among patients undergoing SLN biopsy for breast cancer, the only positive SLN is rarely identified in the 4th or higher node. Terminating the procedure at the 4th node may lower the cost of the procedure and reduce morbidity. J. Surg. Oncol. 2007;96:554–559. © 2007 Wiley-Liss, Inc.en_US
dc.format.extent103685 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherCancer Research, Oncology and Pathologyen_US
dc.titleSentinel lymph node biopsy for breast cancer: How many nodes are enough?en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelOncology and Hematologyen_US
dc.subject.hlbsecondlevelSurgery and Anesthesiologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Pathology, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Surgery, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Surgery, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Surgery, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Surgery, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Surgery, University of Michigan Comprehensive Cancer Center, Ann Arbor, Michigan ; 3304 Cancer Center, 1500 East Medical Center Drive, Ann Arbor, MI 48109-0932; Fax: 734-647-9647.en_US
dc.contributor.affiliationotherDepartment of Surgery, Mayo Clinic, Rochester, Minnesotaen_US
dc.contributor.affiliationotherDepartment of Surgery, Mayo Clinic, Rochester, Minnesotaen_US
dc.identifier.pmid17685432en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/57337/1/20878_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/jso.20878en_US
dc.identifier.sourceJournal of Surgical Oncologyen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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