Growth failure and outcomes in infants with biliary atresia: A report from the Biliary Atresia Research Consortium Potential conflict of interest: Dr. Shneider is on the speakers' bureau of Axcan Scandipharm. Dr. Schwarz received grants from Roche and Gilead.
dc.contributor.author | DeRusso, Patricia A. | en_US |
dc.contributor.author | Ye, Wen | en_US |
dc.contributor.author | Shepherd, Ross | en_US |
dc.contributor.author | Haber, Barbara A. | en_US |
dc.contributor.author | Shneider, Benjamin L. | en_US |
dc.contributor.author | Whitington, Peter F. | en_US |
dc.contributor.author | Schwarz, Kathleen B. | en_US |
dc.contributor.author | Bezerra, Jorge A. | en_US |
dc.contributor.author | Rosenthal, Philip | en_US |
dc.contributor.author | Karpen, Saul | en_US |
dc.contributor.author | Squires, Robert H. | en_US |
dc.contributor.author | Magee, John C. | en_US |
dc.contributor.author | Robuck, Patricia R. | en_US |
dc.contributor.author | Sokol, Ronald J. | en_US |
dc.date.accessioned | 2007-12-04T18:28:07Z | |
dc.date.available | 2008-11-05T15:05:43Z | en_US |
dc.date.issued | 2007-11 | en_US |
dc.identifier.citation | DeRusso, Patricia A.; Ye, Wen; Shepherd, Ross; Haber, Barbara A.; Shneider, Benjamin L.; Whitington, Peter F.; Schwarz, Kathleen B.; Bezerra, Jorge A.; Rosenthal, Philip; Karpen, Saul; Squires, Robert H.; Magee, John C.; Robuck, Patricia R.; Sokol, Ronald J. (2007). "Growth failure and outcomes in infants with biliary atresia: A report from the Biliary Atresia Research Consortium Potential conflict of interest: Dr. Shneider is on the speakers' bureau of Axcan Scandipharm. Dr. Schwarz received grants from Roche and Gilead. ." Hepatology 46(5): 1632-1638. <http://hdl.handle.net/2027.42/57346> | en_US |
dc.identifier.issn | 0270-9139 | en_US |
dc.identifier.issn | 1527-3350 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/57346 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17929308&dopt=citation | |
dc.description.abstract | Malnutrition is a significant clinical problem in infants with biliary atresia. The natural history of poor growth and its potential association with early transplantation or death in children with biliary atresia was determined. Serial weight- and length-for-age z-scores were computed as part of a retrospective study of 100 infants who underwent hepatoportoenterostomy (HPE) for biliary atresia at 9 U.S. pediatric centers between 1997 and 2000. Poor outcome was defined as transplantation or death by 24 months of age (n = 46) and good outcome was defined as survival with native liver at 24 months of age with total serum bilirubin less than 6 mg/dL (n = 54). Growth velocity was significantly slower in the poor outcome group compared to the good outcome group ( P < 0.001 for both weight and length). Mean weight z-scores were significantly lower by 6 months after HPE in the poor outcome group (−2.1 ± 1.4) compared to the good outcome group (−1.2 ± 1.4) ( P < 0.001). In a subgroup with total bilirubin between 2 and 6 mg/dL at 3 months after HPE (n = 28), the weight z-scores at 3 months after HPE were significantly lower in the poor outcome group (−2.0 ±1.2) compared to the good outcome group (−1.0 ± 1.2) ( P = 0.04) despite similar bilirubin concentrations. Conclusion: Growth failure after HPE was associated with transplantation or death by 24 months of age. The combination of intermediate bilirubin concentrations and poor mean weight z-scores 3 months after HPE was also associated with poor clinical outcome. (H EPATOLOGY 2007.) | en_US |
dc.format.extent | 399136 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Hepatology | en_US |
dc.title | Growth failure and outcomes in infants with biliary atresia: A report from the Biliary Atresia Research Consortium Potential conflict of interest: Dr. Shneider is on the speakers' bureau of Axcan Scandipharm. Dr. Schwarz received grants from Roche and Gilead. | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | The University of Michigan, Ann Arbor | en_US |
dc.contributor.affiliationum | The University of Michigan, Ann Arbor ; fax: 734-763-3187 ; University of Michigan Health System, Box 0331, 2926 Taubman Center, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-0331 | en_US |
dc.contributor.affiliationother | Johns Hopkins School of Medicine and The Johns Hopkins Children's Center, Baltimore, Maryland ; Wyeth Pharmaceuticals, Collegeville, Pennsylvania | en_US |
dc.contributor.affiliationother | Washington University School of Medicine and St. Louis Children's Hospital, St. Louis, Missouri | en_US |
dc.contributor.affiliationother | The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania | en_US |
dc.contributor.affiliationother | The Mount Sinai School of Medicine, New York, New York | en_US |
dc.contributor.affiliationother | Children's Memorial Hospital, Chicago, Chicago, Illinois | en_US |
dc.contributor.affiliationother | Johns Hopkins School of Medicine and The Johns Hopkins Children's Center, Baltimore, Maryland | en_US |
dc.contributor.affiliationother | Children's Hospital Medical Center, Cincinnati, Ohio | en_US |
dc.contributor.affiliationother | University of California, San Francisco, San Francisco, California | en_US |
dc.contributor.affiliationother | Texas Children's Hospital and Baylor College of Medicine, Houston, Texas | en_US |
dc.contributor.affiliationother | Children's Hospital, Pittsburgh, Pennsylvania | en_US |
dc.contributor.affiliationother | National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland | en_US |
dc.contributor.affiliationother | University of Colorado School of Medicine and The Children's Hospital, Denver, Colorado | en_US |
dc.identifier.pmid | 17929308 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/57346/1/21923_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/hep.21923 | en_US |
dc.identifier.source | Hepatology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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