Magnetization transfer effects on the efficiency of flow-driven adiabatic fast passage inversion of arterial blood
dc.contributor.author | Hernandez-Garcia, Luis | en_US |
dc.contributor.author | Lewis, David P. | en_US |
dc.contributor.author | Moffat, Bradford | en_US |
dc.contributor.author | Branch, Craig A. | en_US |
dc.date.accessioned | 2007-12-04T18:34:10Z | |
dc.date.available | 2009-01-07T20:01:15Z | en_US |
dc.date.issued | 2007-12 | en_US |
dc.identifier.citation | Hernandez-Garcia, Luis; Lewis, David P.; Moffat, Bradford; Branch, Craig A. (2007). "Magnetization transfer effects on the efficiency of flow-driven adiabatic fast passage inversion of arterial blood." NMR in Biomedicine 20(8): 733-742. <http://hdl.handle.net/2027.42/57383> | en_US |
dc.identifier.issn | 0952-3480 | en_US |
dc.identifier.issn | 1099-1492 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/57383 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17304639&dopt=citation | en_US |
dc.description.abstract | Continuous arterial spin labeling experiments typically use flow-driven adiabatic fast passage inversion of the arterial blood water protons. In this article, we measure the effect of magnetization transfer in blood and how it affects the inversion label. We use modified Bloch equations to model flow-driven adiabatic inversion in the presence of magnetization transfer in blood flowing at velocities from 1 to 30 cm/s in order to explain our findings. Magnetization transfer results in a reduction of the inversion efficiency at the inversion plane of up to 3.65% in the range of velocities examined, as well as faster relaxation of the arterial label in continuous labeling experiments. The two effects combined can result in inversion efficiency reduction of up to 8.91% in the simulated range of velocities. These effects are strongly dependent on the velocity of the flowing blood, with 10 cm/s yielding the largest loss in efficiency due to magnetization transfer effects. Flowing blood phantom experiments confirmed faster relaxation of the inversion label than that predicted by T 1 decay alone. Copyright © 2007 John Wiley & Sons, Ltd. | en_US |
dc.format.extent | 307296 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | John Wiley & Sons, Ltd. | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Analytical Chemistry and Spectroscopy | en_US |
dc.title | Magnetization transfer effects on the efficiency of flow-driven adiabatic fast passage inversion of arterial blood | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Electrical Engineering | en_US |
dc.subject.hlbsecondlevel | Physics | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | FMRI Laboratory, University of Michigan, Ann Arbor, MI, USA ; University of Michigan FMRI Laboratory, 2360 Bonisteel Ave., Ann Arbor, MI 28109-2108, USA. | en_US |
dc.contributor.affiliationum | Department of Radiology, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationother | Center for Advanced Brain Imaging & Division of Medical Physics, The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA ; Department of Radiology and Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA | en_US |
dc.contributor.affiliationother | Center for Advanced Brain Imaging & Division of Medical Physics, The Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY, USA ; Department of Radiology and Neuroscience, Albert Einstein College of Medicine, Bronx, NY, USA | en_US |
dc.identifier.pmid | 17304639 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/57383/1/1137_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/nbm.1137 | en_US |
dc.identifier.source | NMR in Biomedicine | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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