Computed tomography-based tissue-engineered scaffolds in craniomaxillofacial surgery
dc.contributor.author | Smith, M. H. | en_US |
dc.contributor.author | Flanagan, Colleen L. | en_US |
dc.contributor.author | Kemppainen, Jessica Marie | en_US |
dc.contributor.author | Sack, J. A. | en_US |
dc.contributor.author | Chung, H. | en_US |
dc.contributor.author | Das, S. | en_US |
dc.contributor.author | Hollister, Scott J. | en_US |
dc.contributor.author | Feinberg, Stephen E. | en_US |
dc.date.accessioned | 2007-12-04T18:35:29Z | |
dc.date.available | 2008-09-08T14:25:12Z | en_US |
dc.date.issued | 2007-09 | en_US |
dc.identifier.citation | Smith, M. H.; Flanagan, C. L.; Kemppainen, J. M.; Sack, J. A.; Chung, H.; Das, S.; Hollister, S. J.; Feinberg, S. E. (2007). "Computed tomography-based tissue-engineered scaffolds in craniomaxillofacial surgery." The International Journal of Medical Robotics and Computer Assisted Surgery 3(3): 207-216. <http://hdl.handle.net/2027.42/57391> | en_US |
dc.identifier.issn | 1478-5951 | en_US |
dc.identifier.issn | 1478-596X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/57391 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17631675&dopt=citation | en_US |
dc.description.abstract | Introduction Tissue engineering provides an alternative modality allowing for decreased morbidity of donor site grafting and decreased rejection of less compatible alloplastic tissues. Methods Using image-based design and computer software, a precisely sized and shaped scaffold for osseous tissue regeneration can be created via selective laser sintering. Polycaprolactone has been used to create a condylar ramus unit (CRU) scaffold for application in temporomandibular joint reconstruction in a Yucatan minipig animal model. Following sacrifice, micro-computed tomography and histology was used to demonstrate the efficacy of this particular scaffold design. Results A proof-of-concept surgery has demonstrated cartilaginous tissue regeneration along the articulating surface with exuberant osseous tissue formation. Bone volumes and tissue mineral density at both the 1 and 3 month time points demonstrated significant new bone growth interior and exterior to the scaffold. Conclusion Computationally designed scaffolds can support masticatory function in a large animal model as well as both osseous and cartilage regeneration. Our group is continuing to evaluate multiple implant designs in both young and mature Yucatan minipig animals. Copyright © 2007 John Wiley & Sons, Ltd. | en_US |
dc.format.extent | 3398601 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | John Wiley & Sons, Ltd. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Medicine | en_US |
dc.title | Computed tomography-based tissue-engineered scaffolds in craniomaxillofacial surgery | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Surgery and Anesthesiology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Surgery, Division of Oral and Maxillofacial Surgery, University of Michigan, Ann Arbor, MI, USA ; Department of Surgery, Division of Oral and Maxillofacial Surgery, 1500 E. Medical Center Dr., TC B1-208, Ann Arbor, MI 48109-0018, USA. | en_US |
dc.contributor.affiliationum | College of Engineering, Departments of Biomedical Engineering and Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | College of Engineering, Departments of Biomedical Engineering and Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | College of Engineering, Departments of Biomedical Engineering and Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | College of Engineering, Departments of Biomedical Engineering and Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | College of Engineering, Departments of Biomedical Engineering and Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | College of Engineering, Departments of Biomedical Engineering and Mechanical Engineering, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.contributor.affiliationum | Department of Surgery, Division of Oral and Maxillofacial Surgery, University of Michigan, Ann Arbor, MI, USA | en_US |
dc.identifier.pmid | 17631675 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/57391/1/143_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/rcs.143 | en_US |
dc.identifier.source | The International Journal of Medical Robotics and Computer Assisted Surgery | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.