Liver biopsy results in patients with sickle cell disease on chronic transfusions: Poor correlation with ferritin levels
dc.contributor.author | Karam, Lina B. | en_US |
dc.contributor.author | Disco, Deborah | en_US |
dc.contributor.author | Jackson, Sherron M. | en_US |
dc.contributor.author | Lewin, David | en_US |
dc.contributor.author | Mckie, Virgil | en_US |
dc.contributor.author | Baker, Robert D. | en_US |
dc.contributor.author | Baker, Susan S. | en_US |
dc.contributor.author | Laver, Joseph H. | en_US |
dc.contributor.author | Nietert, Paul J. | en_US |
dc.contributor.author | Abboud, Miguel R. | en_US |
dc.date.accessioned | 2007-12-04T18:36:51Z | |
dc.date.available | 2009-01-07T20:01:15Z | en_US |
dc.date.issued | 2008-01 | en_US |
dc.identifier.citation | Karam, Lina B.; Disco, Deborah; Jackson, Sherron M.; Lewin, David; Mckie, Virgil; Baker, Robert D.; Baker, Susan S.; Laver, Joseph H.; Nietert, Paul J.; Abboud, Miguel R. (2008). "Liver biopsy results in patients with sickle cell disease on chronic transfusions: Poor correlation with ferritin levels." Pediatric Blood & Cancer 50(1): 62-65. <http://hdl.handle.net/2027.42/57399> | en_US |
dc.identifier.issn | 1545-5009 | en_US |
dc.identifier.issn | 1545-5017 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/57399 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17457853&dopt=citation | en_US |
dc.description.abstract | Background: Chronic transfusions are effective in preventing stroke and other complications of sickle cell disease. The aim of this study was to determine whether serum ferritin levels correlated with liver iron content in sickle cell patients on chronic transfusion. Procedure: Forty-four liver biopsy specimens from 38 patients with homozygous sickle cell anemia (HbSS) and one patient with sickle thalassemia receiving chronic transfusions were studied. Five patients underwent a second liver biopsy for follow up. Three ferritin measurements were used to calculate a mean for each patient. The association between serum ferritin levels and liver iron quantitation was measured using the Spearman rank correlation, and sensitivity and specificity were determined for selected threshold values of serum ferritin. Results: Serum ferritin levels ranged from 515 to 6076 ng/ml, liver iron concentration ranged from 1.8 to 67.97 mg/g dry weight. The amount of iron per gram liver dry weight was moderately correlated with serum ferritin values ( r = 0.46). The correlation of duration of transfusion with serum ferritin ( r = 0.40) and with liver iron content ( r = 0.41) also indicated moderate correlation. Liver biopsy results led to changes in the management after 29/44 (66%) of the biopsies. Serum ferritin ≥2500 ng/ml predicted high liver iron content (≥7 mg/g), with a sensitivity of 62.5% and a specificity of 77.8%. Conclusion: We found a poor correlation between serum ferritin levels and liver iron content (LIC). Despite being on chelation therapy, many patients on chronic transfusion had high levels of liver iron. Measurement of LIC is highly recommended in these patients. Pediatr Blood Cancer 2008;50:62–65. © 2007 Wiley-Liss, Inc. | en_US |
dc.format.extent | 140572 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Liver biopsy results in patients with sickle cell disease on chronic transfusions: Poor correlation with ferritin levels | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pediatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Pediatric Gastroenterology, University of Michigan-Medical Center, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Medical University of South Carolina, Charleston, South Carolina | en_US |
dc.contributor.affiliationother | Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Medical College of Georgia, Augusta, Georgia | en_US |
dc.contributor.affiliationother | Children's Hospital of Buffalo, Digestive Diseases and Nutrition Center, Buffalo, New York | en_US |
dc.contributor.affiliationother | Children's Hospital of Buffalo, Digestive Diseases and Nutrition Center, Buffalo, New York | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Virginia Commonwealth University, Richmond, Virginia | en_US |
dc.contributor.affiliationother | Department of Biostatistics, Bioinformatics, and Epidemiology, Medical University of South Carolina, Charleston, South Carolina | en_US |
dc.contributor.affiliationother | Children's Cancer Center of Lebanon, American University of Beirut-Medical Center, Beirut, Lebanon ; Professor of Pediatrics, Children's Cancer Center of Lebanon, American University of Beirut-Medical Center, P.O. Box 11-0236, Beirut, Lebanon. | en_US |
dc.identifier.pmid | 17457853 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/57399/1/21215_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/pbc.21215 | en_US |
dc.identifier.source | Pediatric Blood & Cancer | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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