Now showing items 1-10 of 10
Induction of glutathione S -transferase-Π in Barrett's metaplasia and Barrett's adenocarcinoma cell lines
(John Wiley & Sons, Inc., 1999-02)
Barrett's metaplasia consists of columnar epithelium that replaces the normal esophageal mucosa in patients with chronic gastroesophageal reflux. Because intestinal-type Barrett's metaplasia is the major risk factor for ...
Distal chromosome 17q loss in Barrett's esophageal and gastric cardia adenocarcinomas: Implications for tumorigenesis
(John Wiley & Sons, Inc., 1998-08)
The molecular genetic mechanisms underlying esophageal cancer are poorly understood. However, a novel gene that may be involved in esophageal carcinogenesis was recently localized by others to distal 17q by linkage analysis ...
Reduced selenium-binding protein 1 expression is associated with poor outcome in lung adenocarcinomas
(John Wiley & Sons, Ltd., 2004-03)
The effects of selenium, an essential nutrient with anti-carcinogenic properties, are mediated by selenium-binding proteins. The protein expression status of human selenium-binding protein 1 (SBP1) in human tumours and the ...
Finite proliferative lifespan in vitro of a human breast cancer cell strain isolated from a metastatic lymph node
(Kluwer Academic Publishers; Springer Science+Business Media, 1993-01)
We recently described culture conditions that allow proliferation of metastatic human breast cancer cells from biopsy specimens of certain patient samples. These conditions resulted in the development of an immortalized ...
Molecular characterization of FRAXB and comparative common fragile site instability in cancer cells
(John Wiley & Sons, Inc., 2002-01)
The common fragile site, FRA3B, has been shown to be a site of frequent homozygous deletions in some cancers, resulting in loss of expression of the associated FHIT gene. It has been proposed that FHIT is a tumor ...
Multiple forms of genetic instability within a 2-Mb chromosomal segment of 3q26.3–q27 are associated with development of esophageal adenocarcinoma
(Wiley Subscription Services, Inc., A Wiley Company, 2006-04)
Gene amplification is one of the mechanisms to activate oncogenes in many cancers, including esophageal adenocarcinoma (EA). In the present study, we used two-dimensional restriction landmark genome scanning to clone a ...
Identification of intestinal-type Barrett's metaplasia by using the intestine-specific protein villin and esophageal brush cytology
(John Wiley & Sons, Inc., 1999-02)
Villin is an actin-binding cytoskeletal protein required for brush-border formation in the normal small intestinal and renal proximal tubule epithelium. Villin is a marker of cell differentiation in small intestinal and ...
Translocation breakpoints in FHIT and FRA3B in both homologs of chromosome 3 in an esophageal adenocarcinoma
(John Wiley & Sons, Inc., 2001-03)
Common fragile sites have been proposed to play a mechanistic role in chromosome translocations and other rearrangements in cancer cells in vivo based on their behavior in vitro and their co-localization with cancer ...
Automated integration of monolith-based protein separation with on-plate digestion for mass spectrometric analysis of esophageal adenocarcinoma human epithelial samples
(WILEY-VCH Verlag, 2006-09)
A unique approach of automating the integration of monolithic capillary HPLC-based protein separation and on-plate digestion for subsequent MALDI-MS analysis has been developed. All liquid-handling procedures were performed ...
Inhibition of Tumor Necrosis Factor Production by Lymphocytes from Anti-TNF Antibody-Treated, Cardiac-Allografted Rats
(Elsevier, 1994-06)
Tumor necrosis factor-[alpha] (TNF) is a multifunctional cytokine involved in the immunopathologic consequences of allograft rejection. We have previously demonstrated that anti-TNF antibody treatment prolongs cardiac ...