Now showing items 1-5 of 5
Reduced selenium-binding protein 1 expression is associated with poor outcome in lung adenocarcinomas
(John Wiley & Sons, Ltd., 2004-03)
The effects of selenium, an essential nutrient with anti-carcinogenic properties, are mediated by selenium-binding proteins. The protein expression status of human selenium-binding protein 1 (SBP1) in human tumours and the ...
Molecular characterization of FRAXB and comparative common fragile site instability in cancer cells
(John Wiley & Sons, Inc., 2002-01)
The common fragile site, FRA3B, has been shown to be a site of frequent homozygous deletions in some cancers, resulting in loss of expression of the associated FHIT gene. It has been proposed that FHIT is a tumor ...
Multiple forms of genetic instability within a 2-Mb chromosomal segment of 3q26.3–q27 are associated with development of esophageal adenocarcinoma
(Wiley Subscription Services, Inc., A Wiley Company, 2006-04)
Gene amplification is one of the mechanisms to activate oncogenes in many cancers, including esophageal adenocarcinoma (EA). In the present study, we used two-dimensional restriction landmark genome scanning to clone a ...
Translocation breakpoints in FHIT and FRA3B in both homologs of chromosome 3 in an esophageal adenocarcinoma
(John Wiley & Sons, Inc., 2001-03)
Common fragile sites have been proposed to play a mechanistic role in chromosome translocations and other rearrangements in cancer cells in vivo based on their behavior in vitro and their co-localization with cancer ...
Automated integration of monolith-based protein separation with on-plate digestion for mass spectrometric analysis of esophageal adenocarcinoma human epithelial samples
(WILEY-VCH Verlag, 2006-09)
A unique approach of automating the integration of monolithic capillary HPLC-based protein separation and on-plate digestion for subsequent MALDI-MS analysis has been developed. All liquid-handling procedures were performed ...