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Potential outcome measures and trial design issues for multiple system atrophy Members of “The North American Multiple System Atrophy Study Group” are listed as an Appendix .

dc.contributor.authorMay, Susanneen_US
dc.contributor.authorGilman, Siden_US
dc.contributor.authorSowell, B. Brookeen_US
dc.contributor.authorThomas, Ronald G.en_US
dc.contributor.authorStern, Matthew B.en_US
dc.contributor.authorColcher, Amyen_US
dc.contributor.authorTanner, Caroline M.en_US
dc.contributor.authorHuang, Nengen_US
dc.contributor.authorNovak, Peteren_US
dc.contributor.authorReich, Stephen G.en_US
dc.contributor.authorJankovic, Josephen_US
dc.contributor.authorOndo, William G.en_US
dc.contributor.authorLow, Phillip A.en_US
dc.contributor.authorSandroni, Paolaen_US
dc.contributor.authorLipp, Axelen_US
dc.contributor.authorMarshall, Frederick J.en_US
dc.contributor.authorWooten, Fredericken_US
dc.contributor.authorShults, Clifford W.en_US
dc.date.accessioned2008-01-04T20:09:23Z
dc.date.available2009-01-07T20:01:16Zen_US
dc.date.issued2007-12en_US
dc.identifier.citationMay, Susanne; Gilman, Sid; Sowell, B. Brooke; Thomas, Ronald G.; Stern, Matthew B.; Colcher, Amy; Tanner, Caroline M.; Huang, Neng; Novak, Peter; Reich, Stephen G.; Jankovic, Joseph; Ondo, William G.; Low, Phillip A.; Sandroni, Paola; Lipp, Axel; Marshall, Frederick J.; Wooten, Frederick; Shults, Clifford W. (2007). "Potential outcome measures and trial design issues for multiple system atrophy Members of “The North American Multiple System Atrophy Study Group” are listed as an Appendix . ." Movement Disorders 22(16): 2371-2377. <http://hdl.handle.net/2027.42/57524>en_US
dc.identifier.issn0885-3185en_US
dc.identifier.issn1531-8257en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/57524
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17914727&dopt=citationen_US
dc.description.abstractMultiple system atrophy (MSA) is a neurodegenerative disorder exhibiting a combination of parkinsonism, cerebellar ataxia, and autonomic failure. A disease-specific scale, the Unified Multiple System Atrophy Rating Scale (UMSARS), has been developed and validated to measure progression of MSA, but its use as an outcome measure for therapeutic trials has not been evaluated. On the basis of twelve months of follow-up from an observational study of 67 patients with probable MSA, we evaluated three disease-specific scores: Activities of Daily Living, Motor Examination, and a combined score from the UMSARS and two general health scores, the Physical Health and Mental Health scores of the SF-36 health survey, for their use as outcome measures in a therapeutic trial. We discuss related design issues and provide sample size estimates. Scores based on the disease-specific UMSARS seemed to be equal or superior to scores based on the SF-36 health survey. They appeared to capture disease progression, were well correlated and required the smallest sample size. The UMSARS Motor Examination score exhibited the most favorable characteristics as an outcome measure for a therapeutic trial in MSA with 1 year of follow-up. © 2007 Movement Disorder Societyen_US
dc.format.extent95531 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherNeurologyen_US
dc.subject.otherNeuroscienceen_US
dc.titlePotential outcome measures and trial design issues for multiple system atrophy Members of “The North American Multiple System Atrophy Study Group” are listed as an Appendix .en_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Neurology, University of Michigan, Ann Arbor, Michigan, USAen_US
dc.contributor.affiliationotherDepartment of Family and Preventive Medicine, University of California, San Diego, La Jolla, California, USA ; Department of Neurosciences, University of California, San Diego, La Jolla, California, USA ; University of California San Diego, Division of Biostatistics and Bioinformatics, 9500 Gilman Dr.-M/C 0717, La Jolla, CA 92093-0717en_US
dc.contributor.affiliationotherDepartment of Family and Preventive Medicine, University of California, San Diego, La Jolla, California, USAen_US
dc.contributor.affiliationotherDepartment of Family and Preventive Medicine, University of California, San Diego, La Jolla, California, USA ; Department of Neurosciences, University of California, San Diego, La Jolla, California, USAen_US
dc.contributor.affiliationotherParkinson's Disease and Movement Disorders Center, Pennsylvania Hospital, Philadelphia, Pennsylvania, USAen_US
dc.contributor.affiliationotherParkinson's Disease and Movement Disorders Center, Pennsylvania Hospital, Philadelphia, Pennsylvania, USAen_US
dc.contributor.affiliationotherParkinson's Institute, Sunnyvale, California, USAen_US
dc.contributor.affiliationotherParkinson's Institute, Sunnyvale, California, USAen_US
dc.contributor.affiliationotherDepartment of Neurology, Boston University, Boston, Massachusetts, USAen_US
dc.contributor.affiliationotherDepartment of Neurology, University of Maryland, School of Medicine, Baltimore, Maryland, USAen_US
dc.contributor.affiliationotherDepartment of Neurology, Baylor College of Medicine, Houston, Texas, USAen_US
dc.contributor.affiliationotherDepartment of Neurology, Baylor College of Medicine, Houston, Texas, USAen_US
dc.contributor.affiliationotherDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USAen_US
dc.contributor.affiliationotherDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USAen_US
dc.contributor.affiliationotherDepartment of Neurology, Mayo Clinic, Rochester, Minnesota, USAen_US
dc.contributor.affiliationotherDepartment of Neurology, University of Rochester, Rochester, New York, USAen_US
dc.contributor.affiliationotherDepartment of Neurology, University of Virginia Health System, Charlottesville, Virginia, USAen_US
dc.contributor.affiliationotherDepartment of Neurosciences, University of California, San Diego, La Jolla, California, USA ; Veterans Affairs San Diego Healthcare System, San Diego, California, USA ; This manuscript is dedicated to the memory of Clifford W. Shults, MD.en_US
dc.identifier.pmid17914727en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/57524/1/21734_ftp.pdfen_US
dc.identifier.doihttp://dx.doi.org/10.1002/mds.21734en_US
dc.identifier.sourceMovement Disordersen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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