Recent changes in the treatment of patients with advanced laryngeal cancer
dc.contributor.author | Genden, Eric M. | en_US |
dc.contributor.author | Ferlito, Alfio | en_US |
dc.contributor.author | Rinaldo, Alessandra | en_US |
dc.contributor.author | Silver, Carl E. | en_US |
dc.contributor.author | Fagan, Johannes J. | en_US |
dc.contributor.author | Suárez, Carlos | en_US |
dc.contributor.author | Langendijk, Johannes A. | en_US |
dc.contributor.author | Lefebvre, Jean Louis | en_US |
dc.contributor.author | Bradley, Patrick J. | en_US |
dc.contributor.author | Leemans, C. René | en_US |
dc.contributor.author | Chen, Amy Y. | en_US |
dc.contributor.author | Jose, Jemy | en_US |
dc.contributor.author | Wolf, Gregory T. | en_US |
dc.date.accessioned | 2008-01-04T20:11:06Z | |
dc.date.available | 2009-01-07T20:01:15Z | en_US |
dc.date.issued | 2008-01 | en_US |
dc.identifier.citation | Genden, Eric M.; Ferlito, Alfio; Rinaldo, Alessandra; Silver, Carl E.; Fagan, Johannes J.; SuÁrez, Carlos; Langendijk, Johannes A.; Lefebvre, Jean Louis; Bradley, Patrick J.; Leemans, C. RenÉ; Chen, Amy Y.; Jose, Jemy; Wolf, Gregory T. (2008). "Recent changes in the treatment of patients with advanced laryngeal cancer." Head & Neck 30(1): 103-110. <http://hdl.handle.net/2027.42/57534> | en_US |
dc.identifier.issn | 1043-3074 | en_US |
dc.identifier.issn | 1097-0347 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/57534 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17902151&dopt=citation | en_US |
dc.description.abstract | Since the original data from the Department of Veterans Affairs Laryngeal Cancer Study Group demonstrated that nonsurgical therapy could achieve survival rates comparable to total laryngectomy in selected cases, there has been a progressive increase in employment of nonsurgical therapy for the management of advanced laryngeal cancer. Both neoadjuvant chemotherapy followed by conventionally fractionated or hyperfractioned radiotherapy for chemotherapy responders, or simultaneously administered chemoradiation has resulted in a significant number of patients who achieved cure while preserving their larynges. Nevertheless, combined chemotherapy and external beam radiation is associated with a variety of acute and chronic sequelae that can have a debilitating impact on function and quality of life. Although no therapeutic option is without risk, the decision regarding the modality of therapy for a patient with advanced laryngeal cancer should prompt a careful review of the current surgical techniques available for treatment. Data on quality of life and aging, as well as advances in minimally invasive surgical techniques, are available today that were not available at the time of the Veterans study. Selection of optimal therapy is often complex and raises the question whether the pendulum may have swung too far in the direction of nonsurgical therapy for advanced laryngeal cancer. This article reviews the current options available for a patient with advanced laryngeal cancer and discusses the impact of therapy. © 2007 Wiley Periodicals, Inc. Head Neck, 2008 | en_US |
dc.format.extent | 124152 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Recent changes in the treatment of patients with advanced laryngeal cancer | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Otolaryngology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Otolaryngology–Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Department of Otolaryngology–Head and Neck Surgery, The Mount Sinai Medical Center, New York, New York | en_US |
dc.contributor.affiliationother | Department of Surgical Sciences, ENT Clinic, University of Udine, Udine, Italy ; Department of Surgical Sciences, ENT Clinic, University of Udine, Udine, Italy | en_US |
dc.contributor.affiliationother | Department of Surgical Sciences, ENT Clinic, University of Udine, Udine, Italy | en_US |
dc.contributor.affiliationother | Department of Surgery, Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, New York | en_US |
dc.contributor.affiliationother | Division of Otolaryngology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa | en_US |
dc.contributor.affiliationother | Department of Otolaryngology, Hospital Universitario Central de Asturias, Oviedo, Spain ; Instituto Universitario de OncologÍa del Principado de Asturias, Oviedo, Spain | en_US |
dc.contributor.affiliationother | Department of Radiation Oncology, University Medical Center GrÖningen, University of GrÖningen, GrÖningen, The Netherlands | en_US |
dc.contributor.affiliationother | DÉpartement de CancÉrologie Cervico-Faciale, Centre Oscar Lambret, Lille, France | en_US |
dc.contributor.affiliationother | Department of Otorhinolaryngology–Head and Neck Surgery, Queens Medical Centre, Nottingham, United Kingdom | en_US |
dc.contributor.affiliationother | Department of Otolaryngology–Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands | en_US |
dc.contributor.affiliationother | Department of Otolaryngology, Emory University School of Medicine, Atlanta, Georgia | en_US |
dc.contributor.affiliationother | Department of Otolaryngology, Head and Neck Surgery, Hull Royal Infirmary, Hull, United Kingdom | en_US |
dc.identifier.pmid | 17902151 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/57534/1/20715_ftp.pdf | en_US |
dc.identifier.doi | http://dx.doi.org/10.1002/hed.20715 | en_US |
dc.identifier.source | Head & Neck | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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