Now showing items 1-9 of 9
Synovial Inflammation in Patients with Osteonecrosis of the Femoral Head
(Blackwell Publishing Inc, 2009-08)
Much of the work aimed at elucidating the pathogenesis of osteonecrosis (ON) of the femoral head has focused on bone blood supply, with little attention to the surrounding synovial tissue (ST). We hypothesized that patients ...
Overexpression of Human Intestinal Oligopeptide Transporter in Mammalian Cells via Adenoviral Transduction
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1998-09)
Purpose . Our goals are to establish an in vitro screening system and to evaluate a new approach in improving oral absorption of peptides and peptide-like drugs by overexpression of the human intestinal oligo-peptide ...
The Absence of Accessible Vitronectin Receptors in Differentiated Tissue Hinders Adenoviral-Mediated Gene Transfer to the Intestinal Epithelium In Vitro
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1997-09)
Purpose . Adenoviral (Ad) vectors have been used as efficient tools for gene therapy in various tissues, whereas in some differentiated epithelium transduction efficiency is almost abolished.
Physicochemical Characterization and Solubility Analysis of Thalidomide and Its N-Alkyl Analogs
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2002-01)
Purpose . The present study was primarily aimed at exploring the feasibility of improving percutaneous delivery via chemical manipulation of the thalidomide molecule to form analogs with improved physicochemical properties. ...
Percutaneous Delivery of Thalidomide and Its N-Alkyl Analogs
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 2002-04)
Purpose . The purpose of this study was to determine the permeation parameters of thalidomide and three of its N -alkyl analogs and to establish a correlation between the physicochemical properties of these compounds and ...
Perifollicular transgenic expression of human interleukin-1 receptor antagonist protein following topical application of novel liposome-plasmid dna formulations in vivo
(John Wiley & Sons, Inc., 1997-06)
Expression plasmid DNA for the human interleukin-1 receptor antagonist (IL-1ra) protein was formulated with nonionic:cationic (NC) liposomes or phosphatidylcholine:cationic (PC) liposomes and applied to the auricular skin ...
Deficiency of regulatory B cells increases allergic airway inflammation
(Birkhäuser-Verlag; Birkhäuser Verlag, Basel ; Springer Science+Business Media, 2005-12)
Objective: To investigate the effect of the X-linked immunodeficiency (Xid) B cell defect on the response to the cockroach allergen in mice.
Effect of slow release IL-12 and IL-10 on inflammation, local macrophage function and the regional lymphoid response during mycobacterial (Th1) and schistosomal (Th2) antigen-elicited pulmonary granuloma formation
(Birkhäuser Verlag; Birkhäuser Verlag, Basel, ; Springer Science+Business Media, 1997-03)
Objective and Design: This study examines the local and regional effects of exogenously administered interleukins 10 (IL-10) and 12 (IL-12) on pulmonary granulomas mediated by Th1/type 1-(IFN-<gamma>) and Th2/type 2-(IL-4, ...
Beta Cyclodextrins Enhance Adenoviral-Mediated Gene Delivery to the Intestine
(Kluwer Academic Publishers-Plenum Publishers; Plenum Publishing Corporation ; Springer Science+Business Media, 1998-09)
Purpose . In general, the intestinal epithelium is quite refractory to viral and non-viral methods of gene transfer. In this report, various cyclodextrin formulations were tested for their ability to enhance adenoviral ...