Airborne particulate matter exposure and urinary albumin excretion: The Multi-Ethnic Study of Atherosclerosis
dc.contributor.author | O'Neill, M. S. | |
dc.contributor.author | Diez Roux, Ana V. | |
dc.contributor.author | Auchincloss, Amy H. | |
dc.contributor.author | Green Franklin, T. L. | |
dc.contributor.author | Jacobs, D. R. , Jr. | |
dc.contributor.author | Astor, B. C. | |
dc.contributor.author | Dvonch, Joseph T. | |
dc.contributor.author | Kaufman, J. D. | |
dc.date.accessioned | 2008-01-30T16:19:40Z | |
dc.date.available | 2008-01-30T16:19:40Z | |
dc.date.issued | 2007 | |
dc.identifier.uri | https://hdl.handle.net/2027.42/57886 | |
dc.description.abstract | Objectives: Understanding mechanistic pathways linking airborne particle exposure to cardiovascular health is important for causal inference and setting environmental standards. We evaluated whether urinary albumin excretion, a subclinical marker of microvascular function which predicts cardiovascular events, was associated with ambient particle exposure. Methods: Urinary albumin and creatinine were measured among members of the Multi-Ethnic Study of Atherosclerosis at three visits during 2000-2004. Exposure to PM2.5 and PM10 (g/m3) was estimated from ambient monitors for one month, two months and two decades before visit one. We regressed recent and chronic (20 year) PM exposure on urinary albumin/creatinine ratio (UACR) (mg/g) and microalbuminuria at first exam, controlling for age; race/ethnicity; sex; smoking; secondhand smoke exposure; body mass index; and dietary protein (n=3,901). We also evaluated UACR changes and development of microalbuminuria between the first, and second and third visits which took place at 1.5 to 2 year intervals in relation to chronic PM exposure prior to baseline using mixed models. Results: Chronic and recent particle exposures were not associated with current UACR nor microalbuminuria {per 10 g/m3 increment of chronic PM10 exposure, mean difference in log UACR = -0.02 (CI: -0.07, 0.03) and relative probability of having microalbuminuria = 0.92 (CI: 0.77, 1.08)} We found only weak evidence that albuminuria was accelerated among those chronically exposed to particles: each 10 g/m3 increment in chronic PM10 exposure was associated with a 1.14 relative probability of developing microalbuminuria over 3-4 years, though 95% confidence intervals (CI) included the null (0.96, 1.36). Conclusions: UACR is not a strong mechanistic marker for air pollution¡¦s possible influence on cardiovascular health in this sample. | en_US |
dc.format.extent | 115859 bytes | |
dc.format.mimetype | application/pdf | |
dc.language.iso | en_US | en_US |
dc.publisher | Occupational and Environmental Medicine | en_US |
dc.title | Airborne particulate matter exposure and urinary albumin excretion: The Multi-Ethnic Study of Atherosclerosis | en_US |
dc.type | Article | en_US |
dc.subject.hlbsecondlevel | Public Health | |
dc.subject.hlbtoplevel | Health Sciences | |
dc.contributor.affiliationum | Epidemiology, Department of | en_US |
dc.contributor.affiliationumcampus | Ann Arbor | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/57886/1/Airborne particulate matter exposure and urinary albumin excretion THe Multi Ethnic Study if Atherosclerosis.pdf | en_US |
dc.owningcollname | Epidemiology, Department of (SPH) |
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