A case-control study of the association of the polymorphisms and haplotypes of DNA ligase I with lung and upper-aerodigestive-tract cancers
dc.contributor.author | Lee, Yuan-Chin Amy | en_US |
dc.contributor.author | Morgenstern, Hal | en_US |
dc.contributor.author | Greenland, Sander | en_US |
dc.contributor.author | Tashkin, Donald P. | en_US |
dc.contributor.author | Papp, Jeanette C. | en_US |
dc.contributor.author | Sinsheimer, Janet S | en_US |
dc.contributor.author | Cao, Wei | en_US |
dc.contributor.author | Hashibe, Mia | en_US |
dc.contributor.author | You, Nai-Chieh Y. | en_US |
dc.contributor.author | Mao, Jenny T. | en_US |
dc.contributor.author | Cozen, Wendy | en_US |
dc.contributor.author | Mack, Thomas M. | en_US |
dc.contributor.author | Zhang, Zuo-Feng | en_US |
dc.date.accessioned | 2008-02-04T19:16:13Z | |
dc.date.available | 2009-04-09T15:01:14Z | en_US |
dc.date.issued | 2008-04-01 | en_US |
dc.identifier.citation | Lee, Yuan-Chin Amy; Morgenstern, Hal; Greenland, Sander; Tashkin, Donald P.; Papp, Jeanette; Sinsheimer, Janet; Cao, Wei; Hashibe, Mia; You, Nai-Chieh Y.; Mao, Jenny T.; Cozen, Wendy; Mack, Thomas M.; Zhang, Zuo-Feng (2008). "A case-control study of the association of the polymorphisms and haplotypes of DNA ligase I with lung and upper-aerodigestive-tract cancers." International Journal of Cancer 122(7): 1630-1638. <http://hdl.handle.net/2027.42/57901> | en_US |
dc.identifier.issn | 0020-7136 | en_US |
dc.identifier.issn | 1097-0215 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/57901 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18059021&dopt=citation | |
dc.description.abstract | Tobacco smoking is a major risk factor for lung and upper-aerodigestive-tract (UADT) cancers. One possible mechanism for the associations may be through DNA damage pathways. DNA Ligase I ( LIG1 ) is a DNA repair gene involved in both the nucleotide excision repair (NER) and the base excision repair (BER) pathways. We examined the association of 4 LIG1 polymorphisms with lung and UADT cancers, and their potential interactions with smoking in a population-based case-control study in Los Angeles County. We performed genotyping using the SNPlex method from Applied Biosystems. Logistic regression analyses of 551 lung cancer cases, 489 UADT cancer cases and 948 controls showed the expected associations of tobacco smoking with lung and UADT cancers and new associations between the LIG1 haplotypes and these cancers. For lung cancer, when compared to the most common haplotype (rs20581-rs20580-rs20579-rs439132 = T-C-C-A), the adjusted odds ratio (OR) is 1.2 (95% confidence limits (CL) = 0.95, 1.5) for the CACA haplotype, 1.4 (1.0, 1.9) for the CATA haplotype and 1.8 (1.1, 2.8) for the CCCG haplotype, after controlling for age, gender, race/ethnicity, education and tobacco smoking. We observed weaker associations between the LIG1 haplotypes and UADT cancers. Our findings suggest the LIG1 haplotypes may affect the risk of lung and UADT cancers. © 2007 Wiley-Liss, Inc. | en_US |
dc.format.extent | 132955 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | A case-control study of the association of the polymorphisms and haplotypes of DNA ligase I with lung and upper-aerodigestive-tract cancers | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI ; Department of Environmental Health Sciences, University of Michigan School of Public Health, Ann Arbor, MI | en_US |
dc.contributor.affiliationother | Department of Epidemiology, University of California at Los Angeles School of Public Health, Los Angeles, CA | en_US |
dc.contributor.affiliationother | Department of Epidemiology, University of California at Los Angeles School of Public Health, Los Angeles, CA ; Department of Statistics, University of California at Los Angeles, Los Angeles, CA | en_US |
dc.contributor.affiliationother | Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA | en_US |
dc.contributor.affiliationother | Department of Human Genetics, University of California at Los Angeles, Los Angeles, CA | en_US |
dc.contributor.affiliationother | Department of Human Genetics, University of California at Los Angeles, Los Angeles, CA | en_US |
dc.contributor.affiliationother | Department of Epidemiology, University of California at Los Angeles School of Public Health, Los Angeles, CA | en_US |
dc.contributor.affiliationother | International Agency for Research on Cancer, Lyon, France | en_US |
dc.contributor.affiliationother | Department of Epidemiology, University of California at Los Angeles School of Public Health, Los Angeles, CA | en_US |
dc.contributor.affiliationother | Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA | en_US |
dc.contributor.affiliationother | Department of Preventive Medicine, Keck School of Medicine at University of Southern California, Los Angeles, CA | en_US |
dc.contributor.affiliationother | Department of Preventive Medicine, Keck School of Medicine at University of Southern California, Los Angeles, CA | en_US |
dc.contributor.affiliationother | Department of Epidemiology, University of California at Los Angeles School of Public Health, Los Angeles, CA ; Fax: +310-206-6039. ; Department of Epidemiology, University of California at Los Angeles School of Public Health, 71-225 CHS, Box 951772, 650 Charles E Young Drive, South, Los Angeles, CA, 90095-1772, USA | en_US |
dc.identifier.pmid | 18059021 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/57901/1/23274_ftp.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1002/ijc.23274 | en_US |
dc.identifier.source | International Journal of Cancer | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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