Ethics of sham surgery: Perspective of patients
dc.contributor.author | Frank, Samuel A. | en_US |
dc.contributor.author | Wilson, Renee M. | en_US |
dc.contributor.author | Holloway, Robert G. | en_US |
dc.contributor.author | Zimmerman, Carol | en_US |
dc.contributor.author | Peterson, Derick R. | en_US |
dc.contributor.author | Kieburtz, Karl | en_US |
dc.contributor.author | Kim, Scott Y. H. | en_US |
dc.date.accessioned | 2008-02-04T19:19:28Z | |
dc.date.available | 2009-01-07T20:01:16Z | en_US |
dc.date.issued | 2008-01 | en_US |
dc.identifier.citation | Frank, Samuel A.; Wilson, Renee; Holloway, Robert G.; Zimmerman, Carol; Peterson, Derick R.; Kieburtz, Karl; Kim, Scott Y.H. (2008). "Ethics of sham surgery: Perspective of patients." Movement Disorders 23(1): 63-68. <http://hdl.handle.net/2027.42/57916> | en_US |
dc.identifier.issn | 0885-3185 | en_US |
dc.identifier.issn | 1531-8257 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/57916 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=17960809&dopt=citation | en_US |
dc.description.abstract | Sham surgery is used as a control condition in neurosurgical clinical trials in Parkinson's disease (PD) but remains controversial. This study aimed to assess the perspective of patients with PD and the general public on the use of sham surgery controls. We surveyed consecutive patients from a university-based neurology outpatient clinic and a community-based general internal medicine practice. Background information was provided regarding PD and two possible methods of testing the efficacy of a novel gene transfer procedure, followed by questions that addressed participants' opinions related to the willingness to participate and permissibility of blinded and unblinded trial designs. Two hundred eighty-eight (57.6%) patients returned surveys. Patients with PD expressed less willingness to participate in the proposed gene transfer surgery trials. Unblinded studies received greater support, but a majority would still allow the use of sham surgery. Those in favor of sham surgery were more educated and more likely to use societal perspective rationales. Patients with PD are more cautious about surgical research participation than patients with non-PD. Their policy views were similar to others', with a majority supporting the use of sham controls. Future research needs to determine whether eliciting more considered judgments of laypersons would reveal different levels of support for sham surgery. © 2007 Movement Disorder Society | en_US |
dc.format.extent | 65984 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Neurology | en_US |
dc.subject.other | Neuroscience | en_US |
dc.title | Ethics of sham surgery: Perspective of patients | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Psychiatry, the Bioethics Program, and the Center for Behavioral and Decision Sciences in Medicine, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Department of Neurology, Boston University School of Medicine, Boston, Massachusetts ; 715 Albany St., Collamore 329, Boston, MA 02118 | en_US |
dc.contributor.affiliationother | Department of Neurology, University of Rochester, Rochester, New York | en_US |
dc.contributor.affiliationother | Department of Neurology, University of Rochester, Rochester, New York | en_US |
dc.contributor.affiliationother | Department of Neurology, University of Rochester, Rochester, New York | en_US |
dc.contributor.affiliationother | Department of Biostatistics and Computational Biology, University of Rochester, Rochester, New York | en_US |
dc.contributor.affiliationother | Department of Neurology, University of Rochester, Rochester, New York | en_US |
dc.identifier.pmid | 17960809 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/57916/1/21775_ftp.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1002/mds.21775 | en_US |
dc.identifier.source | Movement Disorders | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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