Effect of zinc supplementation on respiratory tract infections in children with cystic fibrosis
dc.contributor.author | Abdulhamid, Ibrahim | en_US |
dc.contributor.author | Beck, F. W. J. | en_US |
dc.contributor.author | Millard, S. | en_US |
dc.contributor.author | Chen, X. | en_US |
dc.contributor.author | Prasad, Ananda S. | en_US |
dc.date.accessioned | 2008-02-04T19:22:43Z | |
dc.date.available | 2009-03-04T14:20:46Z | en_US |
dc.date.issued | 2008-03 | en_US |
dc.identifier.citation | Abdulhamid, I.; Beck, F.W.J.; Millard, S.; Chen, X.; Prasad, A. (2008). "Effect of zinc supplementation on respiratory tract infections in children with cystic fibrosis." Pediatric Pulmonology 43(3): 281-287. <http://hdl.handle.net/2027.42/57931> | en_US |
dc.identifier.issn | 8755-6863 | en_US |
dc.identifier.issn | 1099-0496 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/57931 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18214943&dopt=citation | |
dc.description.abstract | Zinc (Zn) has significant anti-oxidant and anti-inflammatory activity. Zn deficiency can occur in subsets of patients with cystic fibrosis (CF) especially those with malabsorption and impaired growth. Although supplemental Zn has significantly reduced infections in various disorders, its efficacy has not been thoroughly investigated in CF. We performed a double blind placebo controlled pilot study to investigate the effect of daily 30 mg elemental Zn for 1 year on the rate of respiratory tract infections (RTIs), use of antibiotics and plasma cytokines in 26 children with CF (ages 7–18 years). Plasma Zn, Cu, inflammatory cytokines and ex vivo generation of IL-2 were measured at baseline and at the end of the study. The number of days of oral antibiotics was lower in Zn treated patients compared to placebo ( P = 0.05). However, compared to placebo, the effect of Zn was greater in patients who exhibited low plasma Zn at baseline ( P = 0.02) than those who had plasma Zn levels identical to normal subjects ( P = 0.55). Zn supplementation was marginally effective in reducing percentage increase in plasma IL-6 and IL-8 while increasing the percentage change in ex vivo generation of IL-2 in isolated mononuclear cell. In conclusion, oral intake of 30 mg/day of Zn reduced the number of days of oral antibiotics used to treat RTIs in children with CF. A higher daily Zn dose may be needed to decrease RTIs and modify immune responses. Pediatr Pulmonol. 2008; 43:281–287. © 2008 Wiley-Liss, Inc. | en_US |
dc.format.extent | 98241 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Miscellaneous Medical | en_US |
dc.title | Effect of zinc supplementation on respiratory tract infections in children with cystic fibrosis | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pediatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationother | Pediatric Pulmonary Division, The Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan (CHM), Wayne State University (WSU), Detroit, Michigan ; Pediatric Pulmonary Division, Children's Hospital of Michigan, 3901 Beaubien Blvd, Detroit, MI 48201. | en_US |
dc.contributor.affiliationother | Department of Internal Medicine, WSU, Detroit, Michigan | en_US |
dc.contributor.affiliationother | Pediatric Pulmonary Division, DeVos Children's Hospital, Grand Rapids, Michigan | en_US |
dc.contributor.affiliationother | Pediatric Pulmonary Division, The Carman and Ann Adams Department of Pediatrics, Children's Hospital of Michigan (CHM), Wayne State University (WSU), Detroit, Michigan | en_US |
dc.contributor.affiliationother | Department of Internal Medicine, WSU, Detroit, Michigan | en_US |
dc.identifier.pmid | 18214943 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/57931/1/20771_ftp.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1002/ppul.20771 | en_US |
dc.identifier.source | Pediatric Pulmonology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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