The current state of preclinical prostate cancer animal models
dc.contributor.author | Pienta, Kenneth J. | en_US |
dc.contributor.author | Abate-Shen, Cory | en_US |
dc.contributor.author | Agus, David B. | en_US |
dc.contributor.author | Attar, Ricardo M. | en_US |
dc.contributor.author | Chung, Leland W. K. | en_US |
dc.contributor.author | Greenberg, Norman M. | en_US |
dc.contributor.author | Hahn, William C. | en_US |
dc.contributor.author | Isaacs, John T. | en_US |
dc.contributor.author | Navone, Nora M. | en_US |
dc.contributor.author | Peehl, Donna M. | en_US |
dc.contributor.author | Simons, Jonathon W. | en_US |
dc.contributor.author | Solit, David B. | en_US |
dc.contributor.author | Soule, Howard R. | en_US |
dc.contributor.author | VanDyke, Terry A. | en_US |
dc.contributor.author | Weber, Michael J. | en_US |
dc.contributor.author | Wu, Lily | en_US |
dc.contributor.author | Vessella, Robert L. | en_US |
dc.date.accessioned | 2008-03-31T18:38:51Z | |
dc.date.available | 2009-05-04T19:09:21Z | en_US |
dc.date.issued | 2008-05-01 | en_US |
dc.identifier.citation | Pienta, Kenneth J.; Abate-Shen, Cory; Agus, David B.; Attar, Ricardo M.; Chung, Leland W.K.; Greenberg, Norman M.; Hahn, William C.; Isaacs, John T.; Navone, Nora M.; Peehl, Donna M.; Simons, Jonathon W.; Solit, David B.; Soule, Howard R.; VanDyke, Terry A.; Weber, Michael J.; Wu, Lily; Vessella, Robert L. (2008). "The current state of preclinical prostate cancer animal models." The Prostate 68(6): 629-639. <http://hdl.handle.net/2027.42/58068> | en_US |
dc.identifier.issn | 0270-4137 | en_US |
dc.identifier.issn | 1097-0045 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/58068 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18213636&dopt=citation | |
dc.description.abstract | Prostate cancer continues to be a major cause of morbidity and mortality in men around the world. The field of prostate cancer research continues to be hindered by the lack of relevant preclinical models to study tumorigenesis and to further development of effective prevention and therapeutic strategies. The Prostate Cancer Foundation held a Prostate Cancer Models Working Group (PCMWG) Summit on August 6th and 7th, 2007 to address these issues. The PCMWG reviewed the state of prostate cancer preclinical models and identified the current limitations of cell line, xenograft and genetically engineered mouse models that have hampered the transition of scientific findings from these models to human clinical trials. In addition the PCMWG identified administrative issues that inhibit the exchange of models and impede greater interactions between academic centers and these centers with industry. The PCMWG identified potential solutions for discovery bottlenecks that include: (1) insufficient number of models with insufficient molecular and biologic diversity to reflect human cancer, (2) a lack of understanding of the molecular events that define tumorigenesis, (3) a lack of tools for studying tumor–host interactions, (4) difficulty in accessing model systems across institutions, and (5) addressing why preclinical studies appear not to be predictive of human clinical trials. It should be possible to apply the knowledge gained molecular and epigenetic studies to develop new cell lines and models that mimic progressive and fatal prostate cancer and ultimately improve interventions. Prostate 68: 629–639, 2008. © 2008 Wiley-Liss, Inc. | en_US |
dc.format.extent | 366881 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | The current state of preclinical prostate cancer animal models | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Internal Medicine and Specialties | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | University of Michigan, Departments of Internal Medicine and Urology, Ann Arbor, MI ; 1500 E. Medical Center Drive, 7308 CCC, Ann Arbor, MI 48109. | en_US |
dc.contributor.affiliationother | Columbia University, Herbert Irving Cancer Center, New York, NY | en_US |
dc.contributor.affiliationother | Cedars-Sinai, Louis Warschaw Prostate Cancer Center, Los Angeles, CA | en_US |
dc.contributor.affiliationother | Bristol-Myers Squibb, New Jersey | en_US |
dc.contributor.affiliationother | Emory University, Department of Urology, Atlanta, GA | en_US |
dc.contributor.affiliationother | Fred Hutchinson Cancer Center, Seattle, WA | en_US |
dc.contributor.affiliationother | Harvard University, Dana-Farber Cancer Institute, Department of Medical Oncology, Boston, MA | en_US |
dc.contributor.affiliationother | Johns Hopkins Medical School, Departments of Urology and Oncology, Baltimore, MD | en_US |
dc.contributor.affiliationother | University of Texas, M.D. Anderson Cancer Center, Department of Genitourinary Oncology, Houston, TX | en_US |
dc.contributor.affiliationother | Stanford University, Department of Urology, Stanford, CA | en_US |
dc.contributor.affiliationother | Prostate Cancer Foundation, Santa Monica, CA | en_US |
dc.contributor.affiliationother | Memorial Sloan-Kettering Cancer Center, Department of Genitourinary Oncology, New York, NY | en_US |
dc.contributor.affiliationother | Prostate Cancer Foundation, Santa Monica, CA | en_US |
dc.contributor.affiliationother | University of North Carolina, Department of Genetics, Chapel Hill, NC | en_US |
dc.contributor.affiliationother | University of Virginia, Cancer Center and Department of Microbiology, Charlottesville, VA | en_US |
dc.contributor.affiliationother | University of California-Los Angeles, Department of Urology, Los Angeles, CA | en_US |
dc.contributor.affiliationother | University of Washington School of Medicine, Departments of Urology and Microbiology, Seattle, WA | en_US |
dc.identifier.pmid | 18213636 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/58068/1/20726_ftp.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1002/pros.20726 | en_US |
dc.identifier.source | The Prostate | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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