The transmembrane inner ear (tmie) gene contributes to vestibular and lateral line development and function in the zebrafish ( Danio rerio )
dc.contributor.author | Shen, Yu-Chi | en_US |
dc.contributor.author | Jeyabalan, Anandhi K. | en_US |
dc.contributor.author | Wu, Karen L. | en_US |
dc.contributor.author | Hunker, Kristina L. | en_US |
dc.contributor.author | Kohrman, David C. | en_US |
dc.contributor.author | Thompson, Deborah L. | en_US |
dc.contributor.author | Liu, Dong | en_US |
dc.contributor.author | Barald, Kate F. | en_US |
dc.date.accessioned | 2008-03-31T18:42:34Z | |
dc.date.available | 2009-04-09T15:01:14Z | en_US |
dc.date.issued | 2008-04 | en_US |
dc.identifier.citation | Shen, Yu-Chi; Jeyabalan, Anandhi K.; Wu, Karen L.; Hunker, Kristina L.; Kohrman, David C.; Thompson, Deborah L.; Liu, Dong; Barald, Kate F. (2008). "The transmembrane inner ear (tmie) gene contributes to vestibular and lateral line development and function in the zebrafish ( Danio rerio )." Developmental Dynamics 237(4): 941-952. <http://hdl.handle.net/2027.42/58082> | en_US |
dc.identifier.issn | 1058-8388 | en_US |
dc.identifier.issn | 1097-0177 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/58082 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18330929&dopt=citation | |
dc.description.abstract | The inner ear is a complex organ containing sensory tissue, including hair cells, the development of which is not well understood. Our long-term goal is to discover genes critical for the correct formation and function of the inner ear and its sensory tissue. A novel gene, transmembrane inner ear ( Tmie ), was found to cause hearing-related disorders when defective in mice and humans. A homologous tmie gene in zebrafish was cloned and its expression characterized between 24 and 51 hours post-fertilization. Embryos injected with morpholinos (MO) directed against tmie exhibited circling swimming behavior (∼37%), phenocopying mice with Tmie mutations; semicircular canal formation was disrupted, hair cell numbers were reduced, and maturation of electrically active lateral line neuromasts was delayed. As in the mouse, tmie appears to be required for inner ear development and function in the zebrafish and for hair cell maturation in the vestibular and lateral line systems as well. Developmental Dynamics 237:941–952, 2008. © 2008 Wiley-Liss, Inc. | en_US |
dc.format.extent | 2286216 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley-Liss, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cell & Developmental Biology | en_US |
dc.title | The transmembrane inner ear (tmie) gene contributes to vestibular and lateral line development and function in the zebrafish ( Danio rerio ) | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pediatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Cell and Developmental Biology and Department of Biomedical Engineering, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Cell and Developmental Biology and Department of Biomedical Engineering, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Cell and Developmental Biology and Department of Biomedical Engineering, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Departments of Human Genetics and Otolaryngology, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Departments of Human Genetics and Otolaryngology, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Cell and Developmental Biology and Department of Biomedical Engineering, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Cell and Developmental Biology and Department of Biomedical Engineering, University of Michigan Medical School, Ann Arbor, Michigan ; Department of Cell and Developmental Biology, 3053 BSRB 2200, 109 Zina Pitcher Place, Ann Arbor, MI, 48109-2200 | en_US |
dc.contributor.affiliationother | Institute of Neuroscience, University of Oregon, Eugene, Oregon | en_US |
dc.identifier.pmid | 18330929 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/58082/1/21486_ftp.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1002/dvdy.21486 | en_US |
dc.identifier.source | Developmental Dynamics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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