WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth
dc.contributor.author | Potok, Mary Anne | en_US |
dc.contributor.author | Cha, Kelly B. | en_US |
dc.contributor.author | Hunt, Andrea | en_US |
dc.contributor.author | Brinkmeier, Michelle L. | en_US |
dc.contributor.author | Leitges, Michael | en_US |
dc.contributor.author | Kispert, Andreas | en_US |
dc.contributor.author | Camper, Sally A. | en_US |
dc.date.accessioned | 2008-03-31T18:42:51Z | |
dc.date.available | 2009-04-09T15:01:14Z | en_US |
dc.date.issued | 2008-04 | en_US |
dc.identifier.citation | Potok, Mary Anne; Cha, Kelly B.; Hunt, Andrea; Brinkmeier, Michelle L.; Leitges, Michael; Kispert, Andreas; Camper, Sally A. (2008). "WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth." Developmental Dynamics 237(4): 1006-1020. <http://hdl.handle.net/2027.42/58083> | en_US |
dc.identifier.issn | 1058-8388 | en_US |
dc.identifier.issn | 1097-0177 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/58083 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18351662&dopt=citation | |
dc.description.abstract | We examined the role of WNT signaling in pituitary development by characterizing the pituitary phenotype of three WNT knockout mice and assessing the expression of WNT pathway components. Wnt5a mutants have expanded domains of Fgf10 and bone morphogenetic protein expression in the ventral diencephalon and a reduced domain of LHX3 expression in Rathke's pouch. Wnt4 mutants have mildly reduced cell differentiation, reduced POU1F1 expression, and mild anterior lobe hypoplasia. Wnt4 , Wnt5a double mutants exhibit an additive pituitary phenotype of dysmorphology and mild hypoplasia. Wnt6 mutants have no obvious pituitary phenotype. We surveyed WNT expression and identified transcripts for numerous Wnts , Frizzleds , and downstream pathway members in the pituitary and ventral diencephalon. These findings support the emerging model that WNT signaling affects the pituitary gland via effects on ventral diencephalon signaling, and suggest additional Wnt genes that are worthy of functional studies. Developmental Dynamics 237:1006–1020, 2008. © 2008 Wiley-Liss, Inc. | en_US |
dc.format.extent | 4925153 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley-Liss, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cell & Developmental Biology | en_US |
dc.title | WNT signaling affects gene expression in the ventral diencephalon and pituitary gland growth | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pediatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Human Genetics, University of Michigan, Ann Arbor, Michigan ; Department of Human Genetics, University of Michigan Medical School, 4909 Buhl Building, 1241 Catherine Street, Ann Arbor, MI 48109-0618 | en_US |
dc.contributor.affiliationother | Laboratories for Chronobiology and Signal Transduction, Max Planck Institute of Experimental Endocrinology, Hannover, Germany | en_US |
dc.contributor.affiliationother | Institut fÜr Molekularbiologie, Medizinische Hochschule Hannover, Hannover, Germany | en_US |
dc.identifier.pmid | 18351662 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/58083/1/21511_ftp.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1002/dvdy.21511 | en_US |
dc.identifier.source | Developmental Dynamics | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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