Does gadolinium-based angiography protect against contrast-induced nephropathy?: A systematic review of the literature
dc.contributor.author | Boyden, Thomas F. | en_US |
dc.contributor.author | Gurm, Hitinder S. | en_US |
dc.date.accessioned | 2008-03-31T18:43:53Z | |
dc.date.available | 2009-04-09T15:01:14Z | en_US |
dc.date.issued | 2008-04-01 | en_US |
dc.identifier.citation | Boyden, Thomas F.; Gurm, Hitinder S. (2008). "Does gadolinium-based angiography protect against contrast-induced nephropathy?: A systematic review of the literature." Catheterization and Cardiovascular Interventions 71(5): 687-693. <http://hdl.handle.net/2027.42/58087> | en_US |
dc.identifier.issn | 1522-1946 | en_US |
dc.identifier.issn | 1522-726X | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/58087 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18360867&dopt=citation | |
dc.description.abstract | We evaluated the incidence of contrast-induced nephropathy (CIN) in patients exposed to gadolinium for diagnostic or therapeutic procedures. Background: CIN with iodinated contrast agents is a leading cause of acute renal failure. Gadolinium is often used as an alternative to iodinated contrast in patients at increased risk of CIN. The safety of gadolinium in patients at increased risk of CIN has not been established. Methods and Results: The authors performed a systematic review by searching MEDLINE, ISI Web of Knowledge, Current Contents, Embase, and the Cochrane Central Register of Controlled Trials to identify relevant studies evaluating gadolinium and its associated incidence of CIN. They identified 17 studies that reported both favorable and negative results with regard to the association of gadolinium and CIN. The differences in the results appeared to be dose related. When gadolinium was used in doses of 0.4 mmol/kg or higher, there appeared to be an increased incidence of ARF particularly in patients with preexisting renal insufficiency. Conclusions: Although the evidence base is limited, gadolinium does not appear to be safer than iodinated contrast in patients at risk of CIN. Given the lack of randomized data to support its safety, gadolinium in lieu of iso-osmolar iodinated contrast cannot be advocated in patients at high risk of contrast nephropathy. © 2008 Wiley-Liss, Inc. | en_US |
dc.format.extent | 79016 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cardiovascular Medicine | en_US |
dc.title | Does gadolinium-based angiography protect against contrast-induced nephropathy?: A systematic review of the literature | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan ; Division of Cardiovascular Medicine, University of Michigan Cardiovascular Center, 2A394, 1500 E. Medical Center Drive, Ann Arbor, MI 48109-5853 | en_US |
dc.identifier.pmid | 18360867 | |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/58087/1/21459_ftp.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1002/ccd.21459 | en_US |
dc.identifier.source | Catheterization and Cardiovascular Interventions | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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