A novel system for water soluble protein encapsulation with high efficiency: “Micelles enhanced” polyelectrolyte capsules
dc.contributor.author | Li, Xiaodong | en_US |
dc.contributor.author | Li, Xiaohui | en_US |
dc.contributor.author | Zhang, Jianxiang | en_US |
dc.contributor.author | Zhao, Shifang | en_US |
dc.contributor.author | Shen, Jiacong | en_US |
dc.date.accessioned | 2008-05-12T13:41:31Z | |
dc.date.available | 2009-06-01T20:08:52Z | en_US |
dc.date.issued | 2008-06-01 | en_US |
dc.identifier.citation | Li, Xiaodong; Li, Xiaohui; Zhang, Jianxiang; Zhao, Shifang; Shen, Jiacong (2008). "A novel system for water soluble protein encapsulation with high efficiency: “Micelles enhanced” polyelectrolyte capsules." Journal of Biomedical Materials Research Part A 85A(3): 768-776. <http://hdl.handle.net/2027.42/58582> | en_US |
dc.identifier.issn | 1549-3296 | en_US |
dc.identifier.issn | 1552-4965 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/58582 | |
dc.description.abstract | Novel “micelles enhanced” polyelectrolyte (PE) capsules based on functional templates of hybrid calcium carbonate were fabricated. Evidences suggested that the structure of capsule wall was different from that of conventional PE capsules, and the wall permeability of these PE capsules changed significantly. Lysozyme, a positively charged protein in neutral solution, was studied as a model protein to be encapsulated into the “micelles enhanced” PE capsules. Confocal laser scanning microscope was used to observe the entrapping process in real time, while UV-Vis spectroscope and scanning force microscope measurements suggested the high efficiency of encapsulation. In addition, the fluorescence recovery after photobleaching technique was employed to determine the existence form of deposited molecules. Further studies showed even negatively charged water-soluble peptides or proteins can be encapsulated into these hybrid capsules by modulating the pH value in bulk solution under its isoelectronic point as well. © 2007 Wiley Periodicals, Inc. J Biomed Mater Res, 2008 | en_US |
dc.format.extent | 610332 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Polymer and Materials Science | en_US |
dc.title | A novel system for water soluble protein encapsulation with high efficiency: “Micelles enhanced” polyelectrolyte capsules | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biomedical Engineering | en_US |
dc.subject.hlbtoplevel | Engineering | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biologic and Materials Science, University of Michigan, Ann Arbor, Michigan 48109 | en_US |
dc.contributor.affiliationother | Affiliated Stomatology Hospital, College of Medicine, Zhejiang University, Hangzhou 310027, China ; Department of Polymer Science and Engineering, Institute of Polymer Composite, Zhejiang University, Hangzhou 310027, China ; Affiliated Stomatology Hospital, College of Medicine, Zhejiang University, Hangzhou 310027, China | en_US |
dc.contributor.affiliationother | Department of New Drug Research Center, Faculty of Basic Medicine, Third Military Medical University, Chongqing 400038, China ; Department of New Drug Research Center, Faculty of Basic Medicine, Third Military Medical University, Chongqing 400038, China | en_US |
dc.contributor.affiliationother | Affiliated Stomatology Hospital, College of Medicine, Zhejiang University, Hangzhou 310027, China | en_US |
dc.contributor.affiliationother | Department of Polymer Science and Engineering, Institute of Polymer Composite, Zhejiang University, Hangzhou 310027, China | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/58582/1/31543_ftp.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1002/jbm.a.31543 | en_US |
dc.identifier.source | Journal of Biomedical Materials Research Part A | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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