Dietary flavonoid intake and lung cancer—A population-based case-control study
dc.contributor.author | Cui, Yan | en_US |
dc.contributor.author | Morgenstern, Hal | en_US |
dc.contributor.author | Greenland, Sander | en_US |
dc.contributor.author | Tashkin, Donald P. | en_US |
dc.contributor.author | Mao, Jenny T. | en_US |
dc.contributor.author | Cai, Lin | en_US |
dc.contributor.author | Cozen, Wendy | en_US |
dc.contributor.author | Mack, Thomas M. | en_US |
dc.contributor.author | Lu, Qing-Yi | en_US |
dc.contributor.author | Zhang, Zuo-Feng | en_US |
dc.date.accessioned | 2008-05-12T13:43:45Z | |
dc.date.available | 2009-06-01T20:08:52Z | en_US |
dc.date.issued | 2008-05-15 | en_US |
dc.identifier.citation | Cui, Yan; Morgenstern, Hal; Greenland, Sander; Tashkin, Donald P.; Mao, Jenny T.; Cai, Lin; Cozen, Wendy; Mack, Thomas M.; Lu, Qing-Yi; Zhang, Zuo-Feng (2008). "Dietary flavonoid intake and lung cancer—A population-based case-control study." Cancer 112(10): 2241-2248. <http://hdl.handle.net/2027.42/58589> | en_US |
dc.identifier.issn | 0008-543X | en_US |
dc.identifier.issn | 1097-0142 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/58589 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18327817&dopt=citation | en_US |
dc.description.abstract | BACKGROUND Laboratory studies suggest that flavonoids are antimutagenic and anticarcinogenic. To investigate the associations between commonly consumed flavonoid compounds and lung cancer, the authors conducted a population-based case–control study of 558 lung cancer cases and a group of 837 controls. METHODS Dietary intakes of flavonoids were estimated by combining the intake frequency (collected by a food frequency questionnaire), portion size, and food composition data. Unconditional logistic regression analysis was used to estimate odds ratios (ORs) and 95% confidence limits (95% CLs) with an adjustment for potential confounders, including age, sex, race-ethnicity, years of schooling, smoking status, pack-years of tobacco smoking, and daily energy intake. RESULTS Lung cancer was associated inversely with the consumption of epicatechin (in 10 mg per day increment: OR, 0.64; 95% CL, 0.46–0.88), catechin (4 mg per day increment: OR, 0.49; 95% CL, 0.35–0.70), quercetin (9 mg per day increment: OR, 0.65; 95% CL, 0.44–0.95), and kaempferol (2 mg per day increment: OR, 0.68; 95% CL, 0.51–0.90) among tobacco smokers. There was little association between lung cancer and the flavonoid compounds mentioned above among nonsmokers. Regardless of smoking status, there was little association with total flavonoids: thearubigins, hesperetin, naringenin, and myricetin. In addition, consumption of vegetables, tea, and wine, all of which are rich sources of flavonoids, was associated inversely with lung cancer among tobacco smokers. CONCLUSIONS Certain flavonoid compounds, including epicatechin, catechin, quercetin, and kaempferol, were associated inversely with lung cancer among tobacco smokers, but not among nonsmokers. Further studies of these associations may be warranted. Cancer 2008. © 2008 American Cancer Society. | en_US |
dc.format.extent | 109498 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Dietary flavonoid intake and lung cancer—A population-based case-control study | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Epidemiology, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Office of Health Assessment and Epidemiology, Los Angeles County Department of Public Health, Los Angeles, California | en_US |
dc.contributor.affiliationother | Department of Epidemiology, University of California at Los Angeles, California ; Department of Statistics, University of California at Los Angeles, California | en_US |
dc.contributor.affiliationother | Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California | en_US |
dc.contributor.affiliationother | Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California | en_US |
dc.contributor.affiliationother | Department of Epidemiology, School of Public Health, Fujian Medical University, Fujian, China | en_US |
dc.contributor.affiliationother | Department of Preventive Medicine, Keck School of Medicine at University of Southern California, Los Angeles, California | en_US |
dc.contributor.affiliationother | Department of Preventive Medicine, Keck School of Medicine at University of Southern California, Los Angeles, California | en_US |
dc.contributor.affiliationother | Center for Human Nutrition, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California | en_US |
dc.contributor.affiliationother | Department of Epidemiology, University of California at Los Angeles, California ; Fax: (310) 206-6039 ; Department of Epidemiology, University of California at Los Angeles, 71-225 CHS, Box 951772, 650 Charles E. Young Drive, South, Los Angeles, CA, 90095-1772 | en_US |
dc.identifier.pmid | 18327817 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/58589/1/23398_ftp.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1002/cncr.23398 | en_US |
dc.identifier.source | Cancer | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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