Now showing items 1-10 of 29
Effects of morphine treatment on pro-opiomelanocortin systems in rat brain
(Elsevier, 1990-06-11)
In previous studies to determine whether chronic opiate administration might negatively feedback upon endogenous opioid systems in the CNS, investigators found no changes in steady-state concentrations of opioid peptides ...
The NMDA receptor antagonist MK-801 increases morphine catalepsy and lethality
(Elsevier, 1991-03)
Interactions between excitatory amino acids and opioids were examined by studying the ability of the noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 to affect morphine catalepsy and lethality. MK-801 ...
Short-Term Adrenalectomy Increases Glucocorticoid and Mineralocorticoid Receptor mRNA in Selective Areas of the Developing Hippocampus
(Elsevier, 1993-10)
In the central nervous system, adrenal steroids bind to two different types of corticosteroid receptors: glucocorticoid (GR) or mineralocorticoid (MR). In vitro biochemical and autoradiographic techniques have been used ...
Delta opioid receptor mRNA distribution in the brain: Comparison to delta receptor binding and proenkephalin mRNA
(Elsevier, 1993)
The recent cloning of the mouse delta opioid receptor (Evans et al., 1992; Kieffer et al., 1992) has demonstrated it to be a member of the seven transmembrane G-protein coupled family of neurotransmitter receptors. The ...
[beta]-Endorphin processing and cellular origins in rat spinal cord
(Elsevier, 1992-11)
While enkephalin and dynorphin peptides have been well characterized in the spinal cord, the cellular localization of [beta]-endorphin ([beta]E) and the processing of pro-opiomelanocortin (POMC) to [beta]E and other ...
Inhibition of opiate tolerance by non-competitive receptor antagonists
(Elsevier, 1994-01-07)
Our laboratory and others have previously reported that the non-competitive (NMDA) receptor antagonist, MK-801, interferes with the development of tolerance to the analgesic effects of morphine. The present studies were ...
A comparison of D1 receptor binding and mRNA in rat brain using receptor autoradiographic and in situ hybridization techniques
(Elsevier, 1992-02)
D1, a subtype of the dopamine receptors, is widely distributed in the nervous system and has been shown to be positively coupled to adenylate cyclase. Using a combination of in vitro receptor autoradiographic and in situ ...
Site-directed mutagenesis of the human dopamine D2 receptor
(Elsevier, 1992-10-01)
Based on amino acid sequence and computer modeling, two conflicting three-dimensional models of the dopamine D2 receptor have been proposed. One model (Dahl et al., 1991, Proc. Natl. Acad. Sci. USA 88, 8111) suggests that ...
Mu, delta, and kappa opioid receptor mRNA expression in the rat CNS: An in situ hybridization study
(Wiley-Liss, Inc., 1994-12-15)
The Μ, Δ, and Κ opioid receptors are the three main types of opioid receptors round in the central nervous system (CNS) and periphery. These receptors and the peptides with which they interact are important in a number of ...