Now showing items 31-40 of 51
Summary of a National Institute of Mental Health workshop: developing animal models of anxiety disorders
(Springer-Verlag, 2001-10)
Rationale: There exists a wide range of animal models and measures designed to assess anxiety or fearfulness. However, the relationship between these models and clinical anxiety symptoms and syndromes is unclear. The ...
Combined autoradiographic-immunocytochemical analysis of opioid receptors and opioid peptide neuronal systems in brain
(Elsevier, 1985)
Using adjacent section autoradiography-immunocytochemistry, the distribution of [3H]naloxone binding sites was studied in relation to neuronal systems containing [Leu]enkephalin, dynorphin A, or [beta]-endorphin immunoreactivity ...
Changes in releasability of ACTH and Beta-endorphin with chronic stress
(Elsevier, 1985-02)
The activation of the hypothalamic pituitary adrenal axis by stress is well-known. Using inescapable intermittent footshock as a stressor in rats, we have previously demonstrated a rise in circulating plasma Beta-endorph ...
Acute effects of high-dose thyrotropin releasing hormone infusions in Alzheimer's disease
(Springer-Verlag, 1989-07)
Thyrotropin releasing hormone (TRH) was administered intravenously to ten patients with Alzheimer's Disease (AD) in a high-dose paradigm, thought to maximize central nervous system effects and potentially produce facilitation ...
TRH attenuates scopolamine-induced memory impairment in humans
(Springer-Verlag, 1990-03)
The brain tripeptide thyrotropin-releasing hormone (TRH) has been demonstrated to facilitate cholinergic neurotransmission. To test its interaction with the cholinergic system in humans, high-dose TRH (0.5 mg/kg) or placebo ...
Characterization of pro-opiomelanocortin processing in heterologous neuronal cells that express PC2 mRNA
(Elsevier, 1993-05)
We have investigated processing of monkey pro-opiomelanocortin (POMC) following transfection into heterologous neuronal Neuro 2A (N2A) cells. In several separately transfected stable cell lines (termed N2A/POMC2-like; N = ...
Controlled dosing of nicotine via an I ntranasal N icotine A erosol D elivery D evice (INADD)
(Springer-Verlag, 1992-09)
The present report describes an I ntranasal N icotine A erosol D elivery D evice (INADD) employing an artist's airbrush as aerosolizer and precise, electromechanical control of spray duration. It was designed for the ...
Social defeat alters the acquisition of cocaine self-administration in rats: role of individual differences in cocaine-taking behavior
(Springer-Verlag, 2001-12)
Rationale : It is known that social defeat can modulate cocaine self-administration. However, it is unclear whether this psychosocial stressor affects drug-taking behavior to the same extent across all individual animals, ...
A statistical approach for classifying change in cognitive function in individuals following pharmacologic challenge: an example with alprazolam
(Springer-Verlag, 2006-05)
The effects of any drug treatment on cognitive function are typically studied in groups of subjects. Observations made about the behavior of the drug, in the study sample, are then generalized to the population from which ...
The degradation of dynorphin A in brain tissue in vivo and in vitro
(Elsevier, 1987)
The demonstration of analgesia following in vivo administration of dynorphin A (Dyn A) has been difficult. In contrast, a number of electrophysiological and behavioral effects reported with in vivo injection of Dyn A can ...