Now showing items 11-20 of 49
Anatomical relationship between opioid peptides and receptors in rhesus monkey brain
(Elsevier, 1984-12)
To determine whether opioid peptide-receptor pharmacological associations found in vitro (e.g., enkephalin-[delta], dynorphin-[kappa]) predict anatomical relationships in situ, immunocytochemical and receptor autoradiographic ...
Degradation of [3H][beta]-endorphin in rat plasma is increased with chronic stress
(Elsevier, 1989-08-22)
With a number of acute stressors [beta]-endorphin is released into plasma. It is unclear if [beta]-endorphin is converted into any other biologically active products, nor it is clear if the rate or pathways of degradation ...
Anatomy of CNS opioid receptors
(Elsevier, 1988)
There is a wide body of evidence to suggest the existence of at least three distinct opioid receptor types in the CNS, referred to as [mu], [delta], and [kappa]. This paper reviews some of the findings that have led to ...
The preferential release of beta-endorphin from the anterior pituitary lobe by Corticotropin Releasing Factor (CRF)
(Elsevier, 1986)
Although a number of investigators have shown that release of ACTH is accompanied by the release of Beta-endorphin ([beta]-End) and Beta-lipotropin ([beta]-LPH), the proportion of the latter two peptides released with ...
Steady state levels of pro-dynorphin-related end products in the striatum and substantia nigra of the adult rhesus monkey
(Elsevier, 1985)
Analysis of an acid extract of the striatum of the rhesus monkey revealed that the molar ratio of dynorphin A(1-8)-sized material and dynorphin (A(1-17)-sized material is approximately 1:1. In addition, the molar ratios ...
Some of the [alpha]-NH2-acetylated [beta]-endoprhin-like material in rat and monkey pituitary and brain is acetylated [alpha]- and [beta]-endorphin
(Elsevier, 1983)
There are several studies demonstrating the existence of [alpha]-NH2-acetylated (N-Ac) forms of [beta]-endorphin in the intermediate lobe of several species (1,4,6). These include N-Ac-[beta]-endorphin(1-31), N-Ac-[beta] ...
Paradoxical effect of corticosteroids on pituitary ACTH/[beta]-endorphin release in stressed animals
(Elsevier, 1988)
We have previously demonstrated a number of changes in the anterior lobe proopiomelanocortin (POMC) system in chronically stressed rats. The purpose of the present experiments was to investigate whether chronically stressed ...
Behavioral effects of dynorphin1-13 in the mouse and rat: Initial observations
(Elsevier, 1980)
Dynorphin is a recently identified, pharmacologically potent endogenous opioid peptide. Heretofore it has not been characterized for its behavioral effects. The effects of centrally infused dynorphin upon a variety of ...
[D-Ala2,(F5)Phe4]-dynorphin1-13-NH2 (DAFPHEDYN): A potent analog of dynorphin 1-13
(Elsevier, 1987)
Intracerebroventricular administration of the dynorphin analog, [D-Ala2,(F5)Phe4]-dynorphin1-13-NH2 (DAFPHEDYN) in rats produced diuresis and profound analgesia. Both effects were antagonized by central administration of ...