Now showing items 41-50 of 57
Characterization of pro-opiomelanocortin processing in heterologous neuronal cells that express PC2 mRNA
(Elsevier, 1993-05)
We have investigated processing of monkey pro-opiomelanocortin (POMC) following transfection into heterologous neuronal Neuro 2A (N2A) cells. In several separately transfected stable cell lines (termed N2A/POMC2-like; N = ...
Evidence that [beta]-endorphin is synthesized in cells in the nucleus tractus solitarius: detection of POMC mRNA
(Elsevier, 1992-08-07)
Evidence from a number of sources indicates that the major site of pro-opiomelanocortin (POMC)-producing cells in the CNS is the arcuate nucleus of the hypothalamus. Using immunocytochemical techniques, a second, smaller ...
Cloning and characterization of a pharmacologically distinct A1 adenosine receptor from guinea pig brain
(Elsevier, 1994-10)
Three full-length cDNA clones encoding the guinea pig A1 adenosine receptor have been isolated by polymerase chain reaction (PCR) and low-stringency hybridization screening of a guinea pig brain cDNA library. These three ...
Social defeat alters the acquisition of cocaine self-administration in rats: role of individual differences in cocaine-taking behavior
(Springer-Verlag, 2001-12)
Rationale : It is known that social defeat can modulate cocaine self-administration. However, it is unclear whether this psychosocial stressor affects drug-taking behavior to the same extent across all individual animals, ...
Chronic electroconvulsive shock treatment elicits up-regulation of CRF and AVP mRNA in select populations of neuroendocrine neurons
(Elsevier, 1989-11-06)
The effects of repeated electroconvulsive seizures (ECS) on expression of mRNAs coding for corticotropin-releasing factor (CRF) and arginine vasopressin (AVP) in neuroendocrine neurons of the hypothalamo-pituitary-adrenocortical ...
The degradation of dynorphin A in brain tissue in vivo and in vitro
(Elsevier, 1987)
The demonstration of analgesia following in vivo administration of dynorphin A (Dyn A) has been difficult. In contrast, a number of electrophysiological and behavioral effects reported with in vivo injection of Dyn A can ...
Further characterization of the extra-arcuate alpha-melanocyte stimulating hormone-like material in hypothalamus: Biochemical and anatomical studies
(Elsevier, 1986-04)
Previous studies had shown the existence of an extra-arcuate cell group in lateral hypothalamus which contains alpha-melanocyte stimulating hormone (a-MSH)-like immunoreactivity, but no other pro-opiomelanocortin (POMC) ...
Acute systemic administration of morphine selectively increases mu opioid receptor binding in the rat brain
(Elsevier, 1984-12)
Opioid receptor binding, including the mu, delta, and kappa receptor subtypes, was compared in morphine-injected and control rats. Brain tissues were homogenized and centrifuged either one or two times prior to receptor ...
Effects of contextual or olfactory cues previously paired with morphine withdrawal on behavior and pain sensitivity in the rat
(Springer-Verlag, 2001-08)
Rationale: Pavlovian conditioning processes have been accorded an important role in maintaining persistent opiate administration. At least one locus for this contribution is during opiate withdrawal. These experiments ...
The Role of the Hippocampal Mineralocorticoid and Glucocorticoid Receptors in the Hypothalamo-Pituitary-Adrenal Axis of the Aged Fisher Rat
(Elsevier, 1994-10)
The aging process has been frequently associated with hippocampal neuredegeneration, loss of corticosteroid receptors, and, at the same time, dysfunction of the hypothalamo-pituitary-adrenal (HPA) axis. We were interested ...