Now showing items 1-10 of 56
The effects of footshock stress on regional brain dopamine metabolism and pituitary [beta]-endorphin release in rats previously sensitized to amphetamine
(Elsevier, 1987-07)
The repeated intermittent administration of amphetamine (AMP) produces an enduring enhancement in the response of dopamine (DA) systems in the brain to a subsequent "challenge" with amphetamine. However, former amphetamine ...
Selective inhibition by alcohol and cortisol of natural killer cell activity of lymphocytes from cord blood
(Elsevier, 1994-12)
1. 1. The immunosuppressive effects of drugs such as alcohol or hormones such as cortisol may be age-related. To test this hypothesis, the authors investigated the in vitro effects of ethanol (EtOH) and cortisol on Natural ...
Development of hypothalamic opioid neurons: A combined immunocytochemical and [3H]thymidine autoradiographic study
(Elsevier, 1985-02)
Using a combined technique of immunocytochemistry and [3H]thymidine autoradiography, we have determined the "birth-date" of opioid peptide containing neurons in three hypothalamic nuclei. These include proopiomelanocortin ...
Dexamethasone attenuation of the cortisol response to nicotine in smokers
(Springer-Verlag, 1990-06)
The effect of corticosteroids upon the cortisol response to nicotine from smoking was investigated in five heavy smokers. Corticosteroid activity was manipulated by administering dexamethasone, a synthetic glucocortoicoid ...
Enkephalinase: Selective inhibitors and partial characterization
(Elsevier, 1980)
There are at least two types of enzymes in brain, endopeptidases and aminopeptidases, which metabolize enkephalins. Evidence is presented to suggest that enkephalinase, an endopeptidase cleaving at the Gly-Phe bond, is ...
A sensitive coupled HPLC/RIA technique for separation of endorphins: Multiple forms of B-endorphin in rat pituitary intermediate vs. anterior lobe
(Elsevier, 1981-08)
A technique is described which couples High Performance Liquid Chromatography (HPLC) to radioimmuno assays (RIA), thus achieving high sensitivity with good specificity. This method allows the separation and detection of ...
Strategies for studying opioid peptide regulation at the gene, message and protein levels
(Elsevier, 1984)
Three opioid peptide precursors have been isolated and characterized in endocrine and nervous tissue: pro-opiomelanocortin, pro-enkephalin, and pro-dynorphin. Since each of those opioid peptide systems have been extensively ...
Selective effect of alcohol on cellular immune responses of lymphocytes from AIDS patients
(Elsevier, 1994)
In this study we examined the in vitro effects of alcohol on the proliferative responses of lymphocytes from healthy donors and AIDS patients to a recombinant fusion peptide, env-gag, corresponding to portions of the gp ...
Postnatal development of beta-endorphin immunoreactivity in the medulla oblongata of rat
(Elsevier, 1985-02)
Beta-endorphin (B-END) like immunoreactivity (i.r.) levels were measured by radioimmunoassay in the medulla oblongata of developing rats on postnatal ages P1-P42 at 7 day intervals, and in adult rats. From P1 to P42, B-END ...