Now showing items 1-7 of 7
Topiramate attenuates exaggerated acoustic startle in an animal model of PTSD
(Springer-Verlag, 2004-03)
Exaggerated acoustic startle is a prominent symptom of post-traumatic stress disorder (PTSD); however, its physiological basis is not well understood, and there are few available treatments. Neurobiological research has ...
Summary of a National Institute of Mental Health workshop: developing animal models of anxiety disorders
(Springer-Verlag, 2001-10)
Rationale: There exists a wide range of animal models and measures designed to assess anxiety or fearfulness. However, the relationship between these models and clinical anxiety symptoms and syndromes is unclear. The ...
Social defeat alters the acquisition of cocaine self-administration in rats: role of individual differences in cocaine-taking behavior
(Springer-Verlag, 2001-12)
Rationale : It is known that social defeat can modulate cocaine self-administration. However, it is unclear whether this psychosocial stressor affects drug-taking behavior to the same extent across all individual animals, ...
A statistical approach for classifying change in cognitive function in individuals following pharmacologic challenge: an example with alprazolam
(Springer-Verlag, 2006-05)
The effects of any drug treatment on cognitive function are typically studied in groups of subjects. Observations made about the behavior of the drug, in the study sample, are then generalized to the population from which ...
Effects of contextual or olfactory cues previously paired with morphine withdrawal on behavior and pain sensitivity in the rat
(Springer-Verlag, 2001-08)
Rationale: Pavlovian conditioning processes have been accorded an important role in maintaining persistent opiate administration. At least one locus for this contribution is during opiate withdrawal. These experiments ...
Expression of behavioral sensitization to ethanol by DBA/2J mice: the role of NMDA and non-NMDA glutamate receptors
(Springer-Verlag, 2003-05)
Rationale. Behavioral sensitization has been accorded a central role in contemporary theories of drug addiction. Accordingly, a substantial effort has been made to determine the processes mediating sensitization to ...
Chronic administration of the delta opioid receptor agonist (+)BW373U86 and antidepressants on behavior in the forced swim test and BDNF mRNA expression in rats
(Springer-Verlag, 2005-11)
Selective delta opioid receptor agonists have been shown to produce antidepressant-like behavioral effects and increase brain-derived neurotrophic factor (BDNF) mRNA expression when given acutely, but the chronic effects ...