A meta-analysis of the neuropsychological sequelae of chemotherapy-only treatment for pediatric acute lymphoblastic leukemia
dc.contributor.author | Peterson, Catherine C. | en_US |
dc.contributor.author | Johnson, Courtney E. | en_US |
dc.contributor.author | Ramirez, Lisa Y. | en_US |
dc.contributor.author | Huestis, Samantha | en_US |
dc.contributor.author | Pai, Ahna L. H. | en_US |
dc.contributor.author | Demaree, Heath A. | en_US |
dc.contributor.author | Drotar, Dennis | en_US |
dc.date.accessioned | 2008-06-04T14:40:34Z | |
dc.date.available | 2009-07-06T16:34:52Z | en_US |
dc.date.issued | 2008-07 | en_US |
dc.identifier.citation | Peterson, Catherine C.; Johnson, Courtney E.; Ramirez, Lisa Y.; Huestis, Samantha; Pai, Ahna L.H.; Demaree, Heath A.; Drotar, Dennis (2008). "A meta-analysis of the neuropsychological sequelae of chemotherapy-only treatment for pediatric acute lymphoblastic leukemia." Pediatric Blood & Cancer 51(1): 99-104. <http://hdl.handle.net/2027.42/58651> | en_US |
dc.identifier.issn | 1545-5009 | en_US |
dc.identifier.issn | 1545-5017 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/58651 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18322925&dopt=citation | en_US |
dc.description.abstract | Background Mixed findings on the neuropsychological sequelae of chemotherapy-only treatment for pediatric acute lymphoblastic leukemia (ALL), without radiation, indicate the need for a comprehensive meta-analytic review. The purpose of the current study was to conduct a meta-analysis assessing neuropsychological and academic functioning differences between children with ALL treated solely with chemotherapy and comparison groups. Procedure Thirteen articles met inclusion criteria for the meta-analysis and were analyzed using a random effects model, weighted least squares methods. Results Mean effect sizes were significantly different from zero for multiple domains of intelligence and academic achievement; processing speed; verbal memory; and some aspects of executive functioning and fine motor skills, indicating worse functioning in ALL survivors. Effect sizes for visual-motor skills and visual memory were not significantly different from zero. Conclusions Results support the presence of neuropsychological and academic sequelae for ALL survivors treated solely with chemotherapy and highlight the need for ongoing follow-up of children with ALL using a standardized neuropsychological test battery and research methodology. Pediatr Blood Cancer 2008;51:99–104. © 2008 Wiley-Liss, Inc. | en_US |
dc.format.extent | 90507 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | A meta-analysis of the neuropsychological sequelae of chemotherapy-only treatment for pediatric acute lymphoblastic leukemia | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pediatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Division of Child Behavioral Health, Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Michigan ; Division of Child Behavioral Health, University of Michigan Medical School, 1500 East Medical Center Drive, 1924 Taubman Center, Ann Arbor, MI 48109. | en_US |
dc.contributor.affiliationother | Department of Psychology, Case Western Reserve University, Ohio | en_US |
dc.contributor.affiliationother | Department of Psychology, Case Western Reserve University, Ohio | en_US |
dc.contributor.affiliationother | Department of Psychology, Case Western Reserve University, Ohio | en_US |
dc.contributor.affiliationother | Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Ohio | en_US |
dc.contributor.affiliationother | Department of Psychology, Case Western Reserve University, Ohio | en_US |
dc.contributor.affiliationother | Division of Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Ohio | en_US |
dc.identifier.pmid | 18322925 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/58651/1/21544_ftp.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1002/pbc.21544 | en_US |
dc.identifier.source | Pediatric Blood & Cancer | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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