The role of steroid hormones in the NF1 phenotype: Focus on pregnancy How to cite this article: Roth TM, Petty EM, Barald KF. 2008. The role of steroid hormones in the NF1 phenotype: Focus on pregnancy. Am J Med Genet Part A 146A:1624–1633.
dc.contributor.author | Roth, Therese Mary | en_US |
dc.contributor.author | Petty, Elizabeth M. | en_US |
dc.contributor.author | Barald, Kate F. | en_US |
dc.date.accessioned | 2008-06-04T14:41:01Z | |
dc.date.available | 2009-07-06T16:34:52Z | en_US |
dc.date.issued | 2008-06-15 | en_US |
dc.identifier.citation | Roth, Therese M.; Petty, Elizabeth M.; Barald, Kate F. (2008). "The role of steroid hormones in the NF1 phenotype: Focus on pregnancy How to cite this article: Roth TM, Petty EM, Barald KF. 2008. The role of steroid hormones in the NF1 phenotype: Focus on pregnancy. Am J Med Genet Part A 146A:1624–1633. ." American Journal of Medical Genetics Part A 146A(12): 1624-1633. <http://hdl.handle.net/2027.42/58653> | en_US |
dc.identifier.issn | 1552-4825 | en_US |
dc.identifier.issn | 1552-4833 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/58653 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18481270&dopt=citation | en_US |
dc.description.abstract | The Neurofibromatosis Type 1 (NF1) gene functions as a tumor suppressor gene. Loss of its protein, neurofibromin, in the autosomal dominant disorder NF1 is associated with peripheral nervous system tumors, particularly neurofibromas, benign lesions in which the major cell type is the Schwann Cell (SC). Benign and malignant human tumors found in NF1 patients are heterogeneous with respect to their cellular composition. The number and size of neurofibromas in NF1 patients has been shown to increase during pregnancy, with, in some cases, post-partum regression, which suggests hormonal involvement in this increase. However, in this review, we consider evidence from the literature that both direct hormonal influence on tumor growth and on angiogenesis may contribute to these effects. © 2008 Wiley-Liss, Inc. | en_US |
dc.format.extent | 217372 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Genetics | en_US |
dc.title | The role of steroid hormones in the NF1 phenotype: Focus on pregnancy How to cite this article: Roth TM, Petty EM, Barald KF. 2008. The role of steroid hormones in the NF1 phenotype: Focus on pregnancy. Am J Med Genet Part A 146A:1624–1633. | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan ; Department of Human Genetics, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan ; Department of Biomedical Engineering, College of Engineering, University of Michigan Medical School, Ann Arbor, Michigan ; Department of Cell and Developmental Biology, University of Michigan Medical School, 3053 BSRB, 109 Zina Pitcher Place, Ann Arbor, MI 48109-2200. | en_US |
dc.identifier.pmid | 18481270 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/58653/1/32301_ftp.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1002/ajmg.a.32301 | en_US |
dc.identifier.source | American Journal of Medical Genetics Part A | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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