Identification of proteins in human substantia nigra
dc.contributor.author | Kitsou, Efstathia | en_US |
dc.contributor.author | Pan, Sheng | en_US |
dc.contributor.author | Zhang, Jian Peng | en_US |
dc.contributor.author | Shi, Min | en_US |
dc.contributor.author | Zabeti, Aram | en_US |
dc.contributor.author | Dickson, Dennis W. | en_US |
dc.contributor.author | Albin, Roger L. | en_US |
dc.contributor.author | Gearing, Marla | en_US |
dc.contributor.author | Kashima, Daniel T. | en_US |
dc.contributor.author | Wang, Yan | en_US |
dc.contributor.author | Beyer, Richard P. | en_US |
dc.contributor.author | Zhou, Yong | en_US |
dc.contributor.author | Pan, Catherine | en_US |
dc.contributor.author | Caudle, W. Michael | en_US |
dc.contributor.author | Zhang, Jing | en_US |
dc.date.accessioned | 2008-06-04T14:41:40Z | |
dc.date.available | 2009-05-04T19:09:20Z | en_US |
dc.date.issued | 2008-05 | en_US |
dc.identifier.citation | Kitsou, Efstathia; Pan, Sheng; Zhang, JianPeng; Shi, Min; Zabeti, Aram; Dickson, Dennis W.; Albin, Roger; Gearing, Marla; Kashima, Daniel T.; Wang, Yan; Beyer, Richard P.; Zhou, Yong; Pan, Catherine; Caudle, W. Michael; Zhang, Jing (2008). "Identification of proteins in human substantia nigra." PROTEOMICS - Clinical Applications 2(5): 776-782. <http://hdl.handle.net/2027.42/58656> | en_US |
dc.identifier.issn | 1862-8346 | en_US |
dc.identifier.issn | 1862-8354 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/58656 | |
dc.description.abstract | Characterization of the human brain proteome is a critical area of research. While examination of the human cortex has provided some insight, very little is known about the proteome of the human midbrain, which demonstrates substantial loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) in Parkinson's disease (PD). Therefore, characterization of this region is essential to a better understanding of the pathogenesis of PD. This dataset paper reports two separate studies, where human SNpc was collected from PD and control subjects and 1263 proteins were identified using MALDI-TOF/TOF as well as linear ion trap MS platforms. With gene ontology analysis, the proteins were categorized according to their biological processes, as well as cellular components. These data were also compared with previous proteomic characterization of the human frontal and temporal cortex, and cerebrospinal fluid to establish shared proteins of relevance. The present dataset is the most extensive survey of the human SNpc proteome, to date. Further characterization of the SNpc proteome will significantly facilitate our understanding of the function and expression of proteins involved in PD, as well as provide potential proteins that may be utilized as biomarkers. | en_US |
dc.format.extent | 235420 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | WILEY-VCH Verlag | en_US |
dc.subject.other | Life Sciences | en_US |
dc.subject.other | Molecular Cell Biology | en_US |
dc.title | Identification of proteins in human substantia nigra | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Medicine (General) | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Neurology, University of Michigan, and Geriatrics Research, Education, and Clinical Center, Ann Arbor VAHS, MI, USA | en_US |
dc.contributor.affiliationother | Department of Pathology, University of Washington School of Medicine Seattle, Seattle WA, USA | en_US |
dc.contributor.affiliationother | Department of Pathology, University of Washington School of Medicine Seattle, Seattle WA, USA | en_US |
dc.contributor.affiliationother | Department of Pathology, University of Washington School of Medicine Seattle, Seattle WA, USA | en_US |
dc.contributor.affiliationother | Department of Pathology, University of Washington School of Medicine Seattle, Seattle WA, USA | en_US |
dc.contributor.affiliationother | Department of Pathology, University of Washington School of Medicine Seattle, Seattle WA, USA | en_US |
dc.contributor.affiliationother | Department of Pathology, Mayo Clinic, FL, USA | en_US |
dc.contributor.affiliationother | Department of Neurology, Emory University, GA, USA | en_US |
dc.contributor.affiliationother | Department of Pathology, University of Washington School of Medicine Seattle, Seattle WA, USA | en_US |
dc.contributor.affiliationother | Department of Pathology, University of Washington School of Medicine Seattle, Seattle WA, USA | en_US |
dc.contributor.affiliationother | Environmental and Occupational Health Science, University of Washington, Seattle, WA, USA | en_US |
dc.contributor.affiliationother | Institute for Systems Biology, Seattle, WA, USA | en_US |
dc.contributor.affiliationother | Department of Pathology, University of Washington School of Medicine Seattle, Seattle WA, USA | en_US |
dc.contributor.affiliationother | Department of Pathology, University of Washington School of Medicine Seattle, Seattle WA, USA | en_US |
dc.contributor.affiliationother | Department of Pathology, University of Washington School of Medicine Seattle, Seattle WA, USA ; Division of Neuropathology, Harborview Medical Center, University of Washington School of Medicine, BOX 359635, 325 9th Avenue, Seattle, WA 98104-2499, USA Fax: +1-206-341-5249 | en_US |
dc.identifier.pmid | 21136874 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/58656/1/776_ftp.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1002/prca.200800028 | en_US |
dc.identifier.source | PROTEOMICS - Clinical Applications | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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