Factors predicting additional disease in the axilla in patients with positive sentinel lymph nodes after neoadjuvant chemotherapy Presented in part at the Annual Meeting of the American Society of Clinical Oncology, Atlanta, Georgia, June 2–6, 2006.
dc.contributor.author | Jeruss, Jacqueline S. | en_US |
dc.contributor.author | Newman, Lisa A. | en_US |
dc.contributor.author | Ayers, Gregory D. | en_US |
dc.contributor.author | Cristofanilli, Massimo | en_US |
dc.contributor.author | Broglio, Kristine R. | en_US |
dc.contributor.author | Meric-Bernstam, Funda | en_US |
dc.contributor.author | Yi, Min | en_US |
dc.contributor.author | Waljee, Jennifer F. | en_US |
dc.contributor.author | Ross, Merrick I. | en_US |
dc.contributor.author | Hunt, Kelly K. | en_US |
dc.date.accessioned | 2008-07-01T14:06:33Z | |
dc.date.available | 2009-07-06T16:34:52Z | en_US |
dc.date.issued | 2008-06-15 | en_US |
dc.identifier.citation | Jeruss, Jacqueline S.; Newman, Lisa A.; Ayers, Gregory D.; Cristofanilli, Massimo; Broglio, Kristine R.; Meric-Bernstam, Funda; Yi, Min; Waljee, Jennifer F.; Ross, Merrick I.; Hunt, Kelly K. (2008). "Factors predicting additional disease in the axilla in patients with positive sentinel lymph nodes after neoadjuvant chemotherapy Presented in part at the Annual Meeting of the American Society of Clinical Oncology, Atlanta, Georgia, June 2–6, 2006. ." Cancer 112(12): 2646-2654. <http://hdl.handle.net/2027.42/60214> | en_US |
dc.identifier.issn | 0008-543X | en_US |
dc.identifier.issn | 1097-0142 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/60214 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18442039&dopt=citation | en_US |
dc.description.abstract | BACKGROUND. The utility of sentinel lymph node (SNL) biopsy (SLNB) as a predictor of axillary lymph node status is similar in patients who receive neoadjuvant chemotherapy and patients who undergo surgery first. The authors of this study hypothesized that patients with positive SLNs after neoadjuvant therapy would have unique clinicopathologic factors that would be predictive of additional positive non-SLNs distinct from patients who underwent surgery first. METHODS. One hundred four patients were identified who received neoadjuvant chemotherapy, had a positive SLN, and underwent axillary dissection between 1997 and 2005. At the time of presentation, 66 patients had clinically negative lymph nodes by ultrasonography, and 38 patients had positive lymph nodes confirmed by fine-needle aspiration. Eighteen factors were assessed for their ability to predict positive non-SLNs using chi-square and logistic regression analysis with a bootstrapped, backwards elimination procedure. The resulting nomogram was tested by using a patient cohort from another institution. RESULTS. Patients with clinically negative lymph nodes at presentation were less likely than patients with positive lymph nodes to have positive non-SLNs (47% vs 71%; P = .017). On multivariate analysis, lymphovascular invasion, the method for detecting SLN metastasis, multicentricity, positive axillary lymph nodes at presentation, and pathologic tumor size retained grouped significance with a bootstrap-adjusted area under the curve (AUC) of 0.762. The resulting nomogram was validated in the external patient cohort (AUC, 0.78). CONCLUSIONS. A significant proportion of patients with positive SLNs after neoadjuvant chemotherapy had no positive non-SLNs. The use of a nomogram based on 5 predictive variables that were identified in this study may be useful for predicting the risk of positive non-SLNs in patients who have positive SLNs after chemotherapy. Cancer 2008. © 2008 American Cancer Society. | en_US |
dc.format.extent | 149869 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Factors predicting additional disease in the axilla in patients with positive sentinel lymph nodes after neoadjuvant chemotherapy Presented in part at the Annual Meeting of the American Society of Clinical Oncology, Atlanta, Georgia, June 2–6, 2006. | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Oncology and Hematology | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationother | Department Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas | en_US |
dc.contributor.affiliationother | Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, Tennessee | en_US |
dc.contributor.affiliationother | Department of Breast Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas | en_US |
dc.contributor.affiliationother | Division of Quantitative Sciences, The University of Texas M. D. Anderson Cancer Center, Houston Texas | en_US |
dc.contributor.affiliationother | Department Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas | en_US |
dc.contributor.affiliationother | Department Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas | en_US |
dc.contributor.affiliationother | Department Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas | en_US |
dc.contributor.affiliationother | Department Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas ; Fax: (713) 792-4689 ; Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 444, Houston, TX 77030 | en_US |
dc.identifier.pmid | 18442039 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/60214/1/23481_ftp.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1002/cncr.23481 | en_US |
dc.identifier.source | Cancer | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.