Pyrin, product of the MEFV locus, interacts with the proapoptotic protein, Siva Banu Balci Peynircioglu and Andrea L. Waite contributed equally to this study.
dc.contributor.author | Balci-Peynircioglu, Banu | en_US |
dc.contributor.author | Waite, Andrea L. | en_US |
dc.contributor.author | Hu, Chunbo | en_US |
dc.contributor.author | Richards, Neil | en_US |
dc.contributor.author | Staubach-Grosse, Ann | en_US |
dc.contributor.author | Yilmaz, Engin | en_US |
dc.contributor.author | Gumucio, Deborah L. | en_US |
dc.date.accessioned | 2008-07-01T14:07:33Z | |
dc.date.available | 2009-09-02T14:40:29Z | en_US |
dc.date.issued | 2008-09 | en_US |
dc.identifier.citation | Balci-Peynircioglu, Banu; Waite, Andrea L.; Hu, Chunbo; Richards, Neil; Staubach-Grosse, Ann; Yilmaz, Engin; Gumucio, Deborah L. (2008). "Pyrin, product of the MEFV locus, interacts with the proapoptotic protein, Siva Banu Balci Peynircioglu and Andrea L. Waite contributed equally to this study. ." Journal of Cellular Physiology 216(3): 595-602. <http://hdl.handle.net/2027.42/60218> | en_US |
dc.identifier.issn | 0021-9541 | en_US |
dc.identifier.issn | 1097-4652 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/60218 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18330885&dopt=citation | en_US |
dc.description.abstract | Mutations in pyrin cause the autoinflammatory disorder familial Mediterranean fever (FMF), a syndrome characterized by sporadic and unpredictable attacks of fever and localized severe pain. Currently, it is not clear how attacks are triggered, nor why they spontaneously resolve after 2 or 3 days. In fact, the cellular function of the pyrin protein and the molecular underpinnings of its malfunction in FMF have so far eluded clear definition. The identification of pyrin-interacting proteins has the potential to increase our understanding of the cellular networks in which pyrin functions. Previous reports have established that pyrin interacts with the apoptotic protein ASC, the cytoskeletal adaptor protein PSTPIP1, the inflammatory caspase, Caspase-1 and certain forms of the cytosolic anchoring protein 14-3-3. Here, we report that pyrin also interacts with Siva, a pro-apoptotic protein first identified for its interaction with the cytosolic tail of CD27, a TNF family receptor. The interaction between pyrin and Siva involves the C-terminal B30.2/rfp/SRPY domain of pyrin and exon 1 of Siva. We show that Siva and pyrin are indeed co-expressed in human neutrophils, monocytes, and synovial cells. Furthermore, using a novel protein/protein interaction assay, we demonstrate that pyrin can recruit Siva to ASC specks, establishing a potential platform for intersection of ASC and Siva function. Finally, we show that pyrin modulates the apoptotic response to oxidative stress mediated by Siva. Thus, the Siva–pyrin interaction may be a potential target for future therapeutic strategies. J. Cell. Physiol. 216: 595–602, 2008, © 2008 Wiley-Liss, Inc. | en_US |
dc.format.extent | 693537 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cell & Developmental Biology | en_US |
dc.title | Pyrin, product of the MEFV locus, interacts with the proapoptotic protein, Siva Banu Balci Peynircioglu and Andrea L. Waite contributed equally to this study. | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbsecondlevel | Kinesiology and Sports | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Cell and Developmental Biology, University of Michigan Medical School, Ann Arbor, Michigan ; Department of Cell and Developmental Biology, University of Michigan Medical School, 109 Zina Pitcher Place, 2045 BSRB, Ann Arbor, MI 48109-2200. | en_US |
dc.contributor.affiliationother | Department of Medical Biology, Faculty of Medicine, Hacettepe University, Ankara, Turkey | en_US |
dc.contributor.affiliationother | Department of Medical Biology, Faculty of Medicine, Hacettepe University, Ankara, Turkey | en_US |
dc.identifier.pmid | 18330885 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/60218/1/21435_ftp.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1002/jcp.21435 | en_US |
dc.identifier.source | Journal of Cellular Physiology | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
Files in this item
Remediation of Harmful Language
The University of Michigan Library aims to describe library materials in a way that respects the people and communities who create, use, and are represented in our collections. Report harmful or offensive language in catalog records, finding aids, or elsewhere in our collections anonymously through our metadata feedback form. More information at Remediation of Harmful Language.
Accessibility
If you are unable to use this file in its current format, please select the Contact Us link and we can modify it to make it more accessible to you.