Decreased clearance of von Willebrand factor in a patient with type 2B von Willebrand disease following development of immune thrombocytopenia
dc.contributor.author | Wang, Zhihong J. | en_US |
dc.contributor.author | Onwuzurike, Nkechi | en_US |
dc.contributor.author | Callaghan, Michael U. | en_US |
dc.contributor.author | Rajpurkar, Madhvi | en_US |
dc.contributor.author | Chitlur, Meera B. | en_US |
dc.contributor.author | Lusher, Jeanne M. | en_US |
dc.date.accessioned | 2008-08-04T15:13:45Z | |
dc.date.available | 2009-09-02T14:40:29Z | en_US |
dc.date.issued | 2008-09 | en_US |
dc.identifier.citation | Wang, Zhihong J.; Onwuzurike, Nkechi; Callaghan, Michael U.; Rajpurkar, Madhvi; Chitlur, Meera; Lusher, Jeanne M. (2008). "Decreased clearance of von Willebrand factor in a patient with type 2B von Willebrand disease following development of immune thrombocytopenia." Pediatric Blood & Cancer 51(3): 416-418. <http://hdl.handle.net/2027.42/60454> | en_US |
dc.identifier.issn | 1545-5009 | en_US |
dc.identifier.issn | 1545-5017 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/60454 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18493997&dopt=citation | en_US |
dc.description.abstract | We report a case of concurrent type 2B von Willebrand disease (VWD) and immune thrombocytopenia (ITP). The patient had characteristic loss of von Willebrand factor (VWF) high molecular weight multimers (HMWM) but a normal platelet count in the initial 8 years after diagnosis of type 2B VWD. When he developed severe thrombocytopenia, however, both his VWD indices and VWF HMWM normalized. As his platelet count increased, he again lost the HMWM and his VWD indices decreased. These results suggest that the severe thrombocytopenia led to decreased clearance of VWF, especially the HMWM. Pediatr Blood Cancer 2008;51:416–418. © 2008 Wiley-Liss, Inc. | en_US |
dc.format.extent | 127528 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cancer Research, Oncology and Pathology | en_US |
dc.title | Decreased clearance of von Willebrand factor in a patient with type 2B von Willebrand disease following development of immune thrombocytopenia | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pediatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationother | Division of Hematology/Oncology, Children's Hospital of Michigan, Wayne State University, Detroit, Michigan ; Division of Hematology/Oncology, Children's Hospital of Michigan, 3901 Beaubien, Detroit, MI 48201. | en_US |
dc.contributor.affiliationother | Department of Pediatrics, Hurley Medical Center, Flint, Michigan | en_US |
dc.contributor.affiliationother | Division of Hematology/Oncology, Children's Hospital of Michigan, Wayne State University, Detroit, Michigan | en_US |
dc.contributor.affiliationother | Division of Hematology/Oncology, Children's Hospital of Michigan, Wayne State University, Detroit, Michigan | en_US |
dc.contributor.affiliationother | Division of Hematology/Oncology, Children's Hospital of Michigan, Wayne State University, Detroit, Michigan | en_US |
dc.contributor.affiliationother | Division of Hematology/Oncology, Children's Hospital of Michigan, Wayne State University, Detroit, Michigan | en_US |
dc.identifier.pmid | 18493997 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/60454/1/21593_ftp.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1002/pbc.21593 | en_US |
dc.identifier.source | Pediatric Blood & Cancer | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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