CCL2 induces prostate cancer transendothelial cell migration via activation of the small GTPase Rac
dc.contributor.author | van Golen, Kenneth L. | en_US |
dc.contributor.author | Ying, Chi | en_US |
dc.contributor.author | Sequeira, Linda | en_US |
dc.contributor.author | Dubyk, Cara W. | en_US |
dc.contributor.author | Reisenberger, Tracy | en_US |
dc.contributor.author | Chinnaiyan, Arul M. | en_US |
dc.contributor.author | Pienta, Kenneth J. | en_US |
dc.contributor.author | Loberg, Robert D. | en_US |
dc.date.accessioned | 2008-08-04T15:14:29Z | |
dc.date.available | 2009-08-12T18:32:18Z | en_US |
dc.date.issued | 2008-08-01 | en_US |
dc.identifier.citation | van Golen, Kenneth L.; Ying, Chi; Sequeira, Linda; Dubyk, Cara W.; Reisenberger, Tracy; Chinnaiyan, Arul M.; Pienta, Kenneth J.; Loberg, Robert D. (2008). "CCL2 induces prostate cancer transendothelial cell migration via activation of the small GTPase Rac." Journal of Cellular Biochemistry 104(5): 1587-1597. <http://hdl.handle.net/2027.42/60467> | en_US |
dc.identifier.issn | 0730-2312 | en_US |
dc.identifier.issn | 1097-4644 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/60467 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18646053&dopt=citation | en_US |
dc.description.abstract | Nearly 85% of the men who will die of prostate cancer (PCa) have skeletal metastases present. The ability of PCa cells to interact with the microenvironment determines the success of the tumor cell to form metastatic lesions. The ability to bind to human bone marrow endothelial (HBME) cells and undergo transendothelial cell migration are key steps in allowing the PCa cell to extravasate from the bone microvasculature and invade the bone stroma. We have previously demonstrated that monoctyte chemoattractant protein 1 (MCP-1; CCL2) is expressed by HBME cells and promotes PCa proliferation and migration. In the current study, we demonstrate that the CCL2 stimulation of PCa cells activates the small GTPase, Rac through the actin-associated protein PCNT1. Activation of Rac GTPase is accompanied by morphologic changes and the ability of the cells to undergo diapedesis through HBME cells. These data suggest a role for HBME-secreted CCL2 in promoting PCa cell extravasation into the bone microenvironment. J. Cell. Biochem. 104: 1587–1597, 2008. © 2008 Wiley-Liss, Inc. | en_US |
dc.format.extent | 338010 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cell & Developmental Biology | en_US |
dc.title | CCL2 induces prostate cancer transendothelial cell migration via activation of the small GTPase Rac | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Pathology, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan ; Department of Urology, University of Michigan Urology Center, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan ; Department of Urology, University of Michigan Urology Center, Ann Arbor, Michigan ; University of Michigan Urology Center, 7411 CCGC, 1500 E. Medical Center Dr., Ann Arbor, MI 48109-0946. | en_US |
dc.contributor.affiliationother | Department of Biological Science, Laboratory of Cytoskeletal Physiology, University of Delaware, Newark, Delaware ; The Center for Translational Cancer Research, Newark, Delaware | en_US |
dc.contributor.affiliationother | Department of Biological Science, Laboratory of Cytoskeletal Physiology, University of Delaware, Newark, Delaware ; The Center for Translational Cancer Research, Newark, Delaware | en_US |
dc.contributor.affiliationother | Department of Biological Science, Laboratory of Cytoskeletal Physiology, University of Delaware, Newark, Delaware | en_US |
dc.contributor.affiliationother | Department of Biological Science, Laboratory of Cytoskeletal Physiology, University of Delaware, Newark, Delaware | en_US |
dc.identifier.pmid | 18646053 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/60467/1/21652_ftp.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1002/jcb.21652 | en_US |
dc.identifier.source | Journal of Cellular Biochemistry | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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