Inhibitory effects of the macrolide antimicrobial tylosin on anaerobic treatment
dc.contributor.author | Shimada, Toshio | en_US |
dc.contributor.author | Zilles, Julie L. | en_US |
dc.contributor.author | Morgenroth, Eberhard | en_US |
dc.contributor.author | Raskin, Lutgarde | en_US |
dc.date.accessioned | 2008-08-04T15:14:43Z | |
dc.date.available | 2009-09-02T14:40:29Z | en_US |
dc.date.issued | 2008-09-01 | en_US |
dc.identifier.citation | Shimada, Toshio; Zilles, Julie L.; Morgenroth, Eberhard; Raskin, Lutgarde (2008). "Inhibitory effects of the macrolide antimicrobial tylosin on anaerobic treatment." Biotechnology and Bioengineering 101(1): 73-82. <http://hdl.handle.net/2027.42/60471> | en_US |
dc.identifier.issn | 0006-3592 | en_US |
dc.identifier.issn | 1097-0290 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/60471 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18646223&dopt=citation | en_US |
dc.description.abstract | A laboratory-scale anaerobic sequencing batch reactor (ASBR) was operated using a glucose-based synthetic wastewater to study the effects of tylosin, a macrolide antimicrobial commonly used in swine production, on treatment performance. The experimental period was divided into three consecutive phases with different influent tylosin concentrations (0, 1.67, and 167 mg/L). The addition of 1.67 mg/L tylosin to the reactor had negligible effects on the overall treatment performance, that is, total methane production and effluent chemical oxygen demand did not change significantly ( P < 0.05), yet analyses of individual ASBR cycles revealed a decrease in the rates of both methane production and propionate uptake after tylosin was added. The addition of 167 mg/L tylosin to the reactor resulted in a gradual decrease in methane production and the accumulation of propionate and acetate. Subsequent inhibition of methanogenesis was attributed to a decrease in the pH of the reactor. After the addition of 167 mg/L tylosin to the reactor, an initial decrease in the rate of glucose uptake during the ASBR cycle followed by a gradual recovery was observed. In batch tests, the specific biogas production with the substrate butyrate was completely inhibited in the presence of tylosin. This study indicated that tylosin inhibited propionate- and butyrate-oxidizing syntrophic bacteria and fermenting bacteria resulting in unfavorable effects on methanogenesis. Biotechnol. Biotechnol. Bioeng. 2008;101: 73–82. © 2008 Wiley Periodicals, Inc. | en_US |
dc.format.extent | 243034 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Chemistry | en_US |
dc.subject.other | Biochemistry and Biotechnology | en_US |
dc.title | Inhibitory effects of the macrolide antimicrobial tylosin on anaerobic treatment | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Biological Chemistry | en_US |
dc.subject.hlbsecondlevel | Ecology and Evolutionary Biology | en_US |
dc.subject.hlbsecondlevel | Mathematics | en_US |
dc.subject.hlbsecondlevel | Natural Resources and Environment | en_US |
dc.subject.hlbsecondlevel | Statistics and Numeric Data | en_US |
dc.subject.hlbsecondlevel | Public Health | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.subject.hlbtoplevel | Social Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Civil and Environmental Engineering, University of Michigan, 107 EWRE Building, 1351 Beal Ave, Ann Arbor, Michigan 48109-2125; telephone: 734-647-6920; fax: 734-763-2275 ; Department of Civil and Environmental Engineering, University of Michigan, 107 EWRE Building, 1351 Beal Ave, Ann Arbor, Michigan 48109-2125; telephone: 734-647-6920; fax: 734-763-2275. | en_US |
dc.contributor.affiliationother | Department of Civil and Environmental Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois | en_US |
dc.contributor.affiliationother | Department of Civil and Environmental Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois | en_US |
dc.contributor.affiliationother | Department of Civil and Environmental Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois | en_US |
dc.identifier.pmid | 18646223 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/60471/1/21864_ftp.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1002/bit.21864 | en_US |
dc.identifier.source | Biotechnology and Bioengineering | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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