Fungiform papilla pattern: EGF regulates inter-papilla lingual epithelium and decreases papilla number by means of PI3K/Akt, MEK/ERK, and p38 MAPK signaling
dc.contributor.author | Liu, Hong-Xiang | en_US |
dc.contributor.author | Henson, Bradley S. | en_US |
dc.contributor.author | Zhou, Yanqiu | en_US |
dc.contributor.author | D'Silva, Nisha J. | en_US |
dc.contributor.author | Mistretta, Charlotte M. | en_US |
dc.date.accessioned | 2008-10-01T15:23:24Z | |
dc.date.available | 2009-10-02T17:27:37Z | en_US |
dc.date.issued | 2008-09 | en_US |
dc.identifier.citation | Liu, Hong-Xiang; Henson, Bradley S.; Zhou, Yanqiu; D'Silva, Nisha J.; Mistretta, Charlotte M. (2008). "Fungiform papilla pattern: EGF regulates inter-papilla lingual epithelium and decreases papilla number by means of PI3K/Akt, MEK/ERK, and p38 MAPK signaling." Developmental Dynamics 237(9): 2378-2393. <http://hdl.handle.net/2027.42/60977> | en_US |
dc.identifier.issn | 1058-8388 | en_US |
dc.identifier.issn | 1097-0177 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/60977 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18729215&dopt=citation | en_US |
dc.description.abstract | Fungiform papillae are epithelial taste organs that form on the tongue, requiring differentiation of papillae and inter-papilla epithelium. We tested roles of epidermal growth factor (EGF) and the receptor EGFR in papilla development. Developmentally, EGF was localized within and between papillae whereas EGFR was progressively restricted to inter-papilla epithelium. In tongue cultures, EGF decreased papillae and increased cell proliferation in inter-papilla epithelium in a concentration-dependent manner, whereas EGFR inhibitor increased and fused papillae. EGF preincubation could over-ride disruption of Shh signaling that ordinarily would effect a doubling of fungiform papillae. With EGF-induced activation of EGFR, we demonstrated phosphorylation in PI3K/Akt, MEK/ERK, and p38 MAPK pathways; with pathway inhibitors (LY294002, U0126, SB203580) the EGF-mediated decrease in papillae was reversed, and synergistic actions were shown. Thus, EGF/EGFR signaling by means of PI3K/Akt, MEK/ERK, and p38 MAPK contributes to epithelial cell proliferation between papillae; this biases against papilla differentiation and reduces numbers of papillae. Developmental Dynamics 237:2378–2393, 2008. © 2008 Wiley-Liss, Inc. | en_US |
dc.format.extent | 9108726 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley-Liss, Inc. | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cell & Developmental Biology | en_US |
dc.title | Fungiform papilla pattern: EGF regulates inter-papilla lingual epithelium and decreases papilla number by means of PI3K/Akt, MEK/ERK, and p38 MAPK signaling | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Pediatrics | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Oral Health Sciences Ph.D. Program, School of Dentistry, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Periodontics and Oral Medicine, School of Dentistry, and Department of Pathology, Medical School, University of Michigan, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Biologic and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor, Michigan ; Room 6217, School of Dentistry, University of Michigan, Ann Arbor, MI 48109-1078 | en_US |
dc.identifier.pmid | 18729215 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/60977/1/21657_ftp.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1002/dvdy.21657 | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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