Annexin II/Annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer
dc.contributor.author | Shiozawa, Yusuke | en_US |
dc.contributor.author | Havens, Aaron M. | en_US |
dc.contributor.author | Jung, Younghun | en_US |
dc.contributor.author | Ziegler, Anne M. | en_US |
dc.contributor.author | Pedersen, Elisabeth A. | en_US |
dc.contributor.author | Wang, Jingcheng | en_US |
dc.contributor.author | Wang, Jianhua | en_US |
dc.contributor.author | Lu, Ganwei | en_US |
dc.contributor.author | Roodman, G. David | en_US |
dc.contributor.author | Loberg, Robert D. | en_US |
dc.contributor.author | Pienta, Kenneth J. | en_US |
dc.contributor.author | Taichman, Russell S. | en_US |
dc.date.accessioned | 2008-10-01T15:23:43Z | |
dc.date.available | 2009-11-06T18:12:56Z | en_US |
dc.date.issued | 2008-10-01 | en_US |
dc.identifier.citation | Shiozawa, Yusuke; Havens, Aaron M.; Jung, Younghun; Ziegler, Anne M.; Pedersen, Elisabeth A.; Wang, Jingcheng; Wang, Jianhua; Lu, Ganwei; Roodman, G. David; Loberg, Robert D.; Pienta, Kenneth J.; Taichman, Russell S. (2008). "Annexin II/Annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer." Journal of Cellular Biochemistry 105(2): 370-380. <http://hdl.handle.net/2027.42/60982> | en_US |
dc.identifier.issn | 0730-2312 | en_US |
dc.identifier.issn | 1097-4644 | en_US |
dc.identifier.uri | https://hdl.handle.net/2027.42/60982 | |
dc.identifier.uri | http://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18636554&dopt=citation | en_US |
dc.description.abstract | One of the most life-threatening complications of prostate cancer is skeletal metastasis. In order to develop treatment for metastasis, it is important to understand its molecular mechanisms. Our work in this field has drawn parallels between hematopoietic stem cell and prostate cancer homing to the marrow. Our recent work demonstrated that annexin II expressed by osteoblasts and endothelial cells plays a critical role in niche selection. In this study, we demonstrate that annexin II and its receptor play a crucial role in establishing metastasis of prostate cancer. Prostate cancer cell lines migrate toward annexin II and the adhesion of prostate cancer to osteoblasts and endothelial cells was inhibited by annexin II. By blocking annexin II or its receptor in animal models, short-term and long-term localization of prostate cancers are limited. Annexin II may also facilitate the growth of prostate cancer in vitro and in vivo by the MAPK pathway. These data strongly suggest that annexin II and its receptor axis plays a central role in prostate cancer metastasis, and that prostate cancer utilize the hematopoietic stem cell homing mechanisms to gain access to the niche. J. Cell. Biochem. 105: 370–380, 2008. © 2008 Wiley-Liss, Inc. | en_US |
dc.format.extent | 423007 bytes | |
dc.format.extent | 3118 bytes | |
dc.format.mimetype | application/pdf | |
dc.format.mimetype | text/plain | |
dc.publisher | Wiley Subscription Services, Inc., A Wiley Company | en_US |
dc.subject.other | Life and Medical Sciences | en_US |
dc.subject.other | Cell & Developmental Biology | en_US |
dc.title | Annexin II/Annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer | en_US |
dc.type | Article | en_US |
dc.rights.robots | IndexNoFollow | en_US |
dc.subject.hlbsecondlevel | Genetics | en_US |
dc.subject.hlbsecondlevel | Molecular, Cellular and Developmental Biology | en_US |
dc.subject.hlbtoplevel | Health Sciences | en_US |
dc.subject.hlbtoplevel | Science | en_US |
dc.description.peerreviewed | Peer Reviewed | en_US |
dc.contributor.affiliationum | Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan ; Harvard School of Dental Medicine, Boston, Massachusetts | en_US |
dc.contributor.affiliationum | Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Division of Hemotology/Oncology, University of Michigan School of Medicine, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Internal Medicine, Division of Hemotology/Oncology, University of Michigan School of Medicine, Ann Arbor, Michigan | en_US |
dc.contributor.affiliationum | Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan ; Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Room 3307, 1011 North University Avenue, Ann Arbor, MI 48109-1078. | en_US |
dc.contributor.affiliationother | Medicine-Hematology/Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania | en_US |
dc.contributor.affiliationother | Medicine-Hematology/Oncology, University of Pittsburgh, Pittsburgh, Pennsylvania | en_US |
dc.identifier.pmid | 18636554 | en_US |
dc.description.bitstreamurl | http://deepblue.lib.umich.edu/bitstream/2027.42/60982/1/21835_ftp.pdf | |
dc.identifier.doi | http://dx.doi.org/10.1002/jcb.21835 | en_US |
dc.identifier.source | Journal of Cellular Biochemistry | en_US |
dc.owningcollname | Interdisciplinary and Peer-Reviewed |
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