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Annexin II/Annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer

dc.contributor.authorShiozawa, Yusukeen_US
dc.contributor.authorHavens, Aaron M.en_US
dc.contributor.authorJung, Younghunen_US
dc.contributor.authorZiegler, Anne M.en_US
dc.contributor.authorPedersen, Elisabeth A.en_US
dc.contributor.authorWang, Jingchengen_US
dc.contributor.authorWang, Jianhuaen_US
dc.contributor.authorLu, Ganweien_US
dc.contributor.authorRoodman, G. Daviden_US
dc.contributor.authorLoberg, Robert D.en_US
dc.contributor.authorPienta, Kenneth J.en_US
dc.contributor.authorTaichman, Russell S.en_US
dc.date.accessioned2008-10-01T15:23:43Z
dc.date.available2009-11-06T18:12:56Zen_US
dc.date.issued2008-10-01en_US
dc.identifier.citationShiozawa, Yusuke; Havens, Aaron M.; Jung, Younghun; Ziegler, Anne M.; Pedersen, Elisabeth A.; Wang, Jingcheng; Wang, Jianhua; Lu, Ganwei; Roodman, G. David; Loberg, Robert D.; Pienta, Kenneth J.; Taichman, Russell S. (2008). "Annexin II/Annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancer." Journal of Cellular Biochemistry 105(2): 370-380. <http://hdl.handle.net/2027.42/60982>en_US
dc.identifier.issn0730-2312en_US
dc.identifier.issn1097-4644en_US
dc.identifier.urihttps://hdl.handle.net/2027.42/60982
dc.identifier.urihttp://www.ncbi.nlm.nih.gov/sites/entrez?cmd=retrieve&db=pubmed&list_uids=18636554&dopt=citationen_US
dc.description.abstractOne of the most life-threatening complications of prostate cancer is skeletal metastasis. In order to develop treatment for metastasis, it is important to understand its molecular mechanisms. Our work in this field has drawn parallels between hematopoietic stem cell and prostate cancer homing to the marrow. Our recent work demonstrated that annexin II expressed by osteoblasts and endothelial cells plays a critical role in niche selection. In this study, we demonstrate that annexin II and its receptor play a crucial role in establishing metastasis of prostate cancer. Prostate cancer cell lines migrate toward annexin II and the adhesion of prostate cancer to osteoblasts and endothelial cells was inhibited by annexin II. By blocking annexin II or its receptor in animal models, short-term and long-term localization of prostate cancers are limited. Annexin II may also facilitate the growth of prostate cancer in vitro and in vivo by the MAPK pathway. These data strongly suggest that annexin II and its receptor axis plays a central role in prostate cancer metastasis, and that prostate cancer utilize the hematopoietic stem cell homing mechanisms to gain access to the niche. J. Cell. Biochem. 105: 370–380, 2008. © 2008 Wiley-Liss, Inc.en_US
dc.format.extent423007 bytes
dc.format.extent3118 bytes
dc.format.mimetypeapplication/pdf
dc.format.mimetypetext/plain
dc.publisherWiley Subscription Services, Inc., A Wiley Companyen_US
dc.subject.otherLife and Medical Sciencesen_US
dc.subject.otherCell & Developmental Biologyen_US
dc.titleAnnexin II/Annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate canceren_US
dc.typeArticleen_US
dc.rights.robotsIndexNoFollowen_US
dc.subject.hlbsecondlevelGeneticsen_US
dc.subject.hlbsecondlevelMolecular, Cellular and Developmental Biologyen_US
dc.subject.hlbtoplevelHealth Sciencesen_US
dc.subject.hlbtoplevelScienceen_US
dc.description.peerreviewedPeer Revieweden_US
dc.contributor.affiliationumDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan ; Harvard School of Dental Medicine, Boston, Massachusettsen_US
dc.contributor.affiliationumDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Internal Medicine, Division of Hemotology/Oncology, University of Michigan School of Medicine, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Internal Medicine, Division of Hemotology/Oncology, University of Michigan School of Medicine, Ann Arbor, Michiganen_US
dc.contributor.affiliationumDepartment of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Ann Arbor, Michigan ; Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry, Room 3307, 1011 North University Avenue, Ann Arbor, MI 48109-1078.en_US
dc.contributor.affiliationotherMedicine-Hematology/Oncology, University of Pittsburgh, Pittsburgh, Pennsylvaniaen_US
dc.contributor.affiliationotherMedicine-Hematology/Oncology, University of Pittsburgh, Pittsburgh, Pennsylvaniaen_US
dc.identifier.pmid18636554en_US
dc.description.bitstreamurlhttp://deepblue.lib.umich.edu/bitstream/2027.42/60982/1/21835_ftp.pdf
dc.identifier.doihttp://dx.doi.org/10.1002/jcb.21835en_US
dc.identifier.sourceJournal of Cellular Biochemistryen_US
dc.owningcollnameInterdisciplinary and Peer-Reviewed


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